Back to basals: do basal dendrites link plateau potentials and Up states?
Back to basals: do basal dendrites link plateau potentials and Up states?
复制标题
回到基底层：基底树突是否将平台电位和向上状态联系起来？
DOI：
10.1113/jphysiol.2007.146977
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Waters,Jack
中科院分区：
文献类型：
--
作者：
Waters,Jack
One of the aims of cellular neuroscience is to understand how a neurone converts incoming information, in the form of active synapses, into appropriate action potential output. In neurones of the mammalian brain, the postsynaptic structure is usually a dendrite so a neurone’s response to synaptic input is strongly influenced by the properties of its dendritic tree.Much of what we know about the physiological properties of dendrites is derived from research on the apical dendrites of hippocampal and neocortical pyramidal neurones. Pyramidal cells are the main class of excitatory neurones in both hippocampus and neocortex and are therefore central to hippocampal and neocortical function, but this is not why these neurones are the subjects of choice for many dendritic physiologists. The reason is that the apical dendrites of pyramidal neurons are large, making it easier to obtain patch-clamp recordings from apical dendrites than from other, smaller-diameter dendrites. As a result we now understand apical in some depth. However, most synapses are not onto apical dendrites: more than 50% of a cortical pyramidal neurone’s spines are on its basal dendrites (Larkman, 1991).
