Cigarette smoking and heart rate variability: Dynamic influence of parasympathetic and sympathetic maneuvers
Cigarette smoking and heart rate variability: Dynamic influence of parasympathetic and sympathetic maneuvers
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DOI：
10.1111/j.1542-474x.2005.00636.x
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发表时间：
2005-07-01
影响因子：
1.9
通讯作者：
Basaran, Y
中科院分区：
文献类型：
--
作者：
Barutcu, I;Esen, AM;Basaran, Y
背景：吸烟与交感神经系统活动增加有关。在这项研究中，我们通过分析心率变异性 (HRV) 来调查重度吸烟者和非吸烟者对照组的心脏自主功能。方法：24 名长期重度吸烟者（男性）和 22 名非吸烟者（医院工作人员）被纳入研究。所有参与者在仰卧位 (S) 休息 15 分钟、受控呼吸 (CR) 和握力运动 (HGE) 超过 5 分钟期间，获得 HRV 的时域 [平均 R-R 间期 (RR)、R-R 间期指数的标准差 (SDNN) 和连续 R-R 间期差异的均方根 (RMSSD)] 和频域 [高频 (HF) 低频 (LF) 和 LF/HF 比] 参数。 结果：研究发现吸烟者的基线 SDNN 和 RMSSD 值低于不吸烟者。 （64 10 与 78 22，P < 0.05 和 35 12 与 54 30 毫秒，P < 0.05）。还发现吸烟者的基线 LF/HF 比率高于非吸烟者（1.3 +/- 0.6 vs 0.9 +/- 0.5 毫秒，P < 0.05）。其他 HRV 参数包括 R-R 间期、LF 和 HF 没有显着差异。在 CR 期间，吸烟者中的 RR、SDNN 和 RMSSD 并未出现预期的增加，但非吸烟者中却出现了这种情况。两组中大多数 HRV 指数均受到 HGE 的显着影响。此外，吸烟持续时间与 RMSSD 和 HF 呈负相关，与 LF/HF 比率呈正相关。结论：重度吸烟者的心脏迷走神经调节减弱，特别是在副交感神经活动期间。心脏自主控制减弱可能部分与吸烟引起的不良事件有关。
Background: Cigarette smoking has been associated with increased activity of the sympathetic nervous system. In this study, we investigated cardiac autonomic function in heavy smokers and nonsmoker controls by analysis of heart rate variability (HRV).Method: Twenty-four long-term heavy smokers (men) and twenty-two nonsmoker subjects (hospital staff) were included to study. Time domain [mean R-R interval (RR), the standard deviation of R-R interval index (SDNN), and the root mean square of successive R-R interval differences (RMSSD)] and frequency domain [high frequency (HF) low frequency (LF), and LF/HF ratio] parameters of HRV were obtained from all participants after 15 minutes resting period in supine position (S), during controlled respiration (CR), and handgrip exercise (HGE) over 5-minute periods.Results: Baseline SDNN and RMSSD values were found to be lower in smokers than in nonsmokers. (64 10 vs 78 22, P < 0.05 and 35 12 vs 54 30 ms, P < 0.05). Baseline LF/HF ratio was also found to be higher in smokers than in nonsmokers (1.3 +/- 0.6 vs 0.9 +/- 0.5 ms, P < 0.05). The other HRV parameters including R-R interval, LF, and HF were not significantly different. During CR, expected increase in RR, SDNN, and RMSSD did not occur in smokers, while it did occur in nonsmokers. Most HRV indices were significantly affected by HGE in both groups. In addition, the duration of smoking was found to be inversely correlated with RMSSD and HF and positively correlated with LF/HF ratio.Conclusion: Vagal modulation of the heart is blunted in heavy smokers, particularly during a parasympathetic maneuver. Blunted autonomic control of the heart may partly be associated with adverse event attributed to cigarette smoking.