Heterogeneity in the acute control of vascular protein synthesis in vivo
Heterogeneity in the acute control of vascular protein synthesis in vivo
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DOI：
10.1159/000070709
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发表时间：
2003-03-01
影响因子：
1.7
通讯作者：
Moreau, P
中科院分区：
文献类型：
--
作者：
Beaucage, P;Yamaguchi, N;Moreau, P
作为对血流动力学和神经体液变化的响应，心血管系统重塑，并且该过程可能导致终末器官损伤。本研究的目的是确定导管和阻力动脉中已知有助于血管肥厚性重塑的3个系统之间的早期体内相互作用。外源性血管紧张素II，去甲肾上腺素和内皮素1管理升高蛋白质合成的主动脉和小肠系膜动脉。在小动脉中，血管紧张素II的作用被血管紧张素II 1型、α-肾上腺素能和内皮素受体拮抗剂阻断，而只有α-肾上腺素能和内皮素受体拮抗剂抑制去甲肾上腺素的作用。此外，只有内皮素受体拮抗剂显着减弱外源性内皮素对蛋白质合成的影响。在主动脉中，血管紧张素II对蛋白质合成的刺激也被3种拮抗剂抑制。然而，只有α-肾上腺素受体拮抗剂钝化的反应去甲肾上腺素，和3拮抗剂阻止内皮素诱导的蛋白质合成的升高。这些药物的血压效应与其刺激或抑制血管蛋白合成的能力无关。总之，在控制蛋白质合成的相互作用是异质的沿着血管树。在小动脉中，相互作用与作为下游效应物的内皮素呈线性。在主动脉中，局部交感神经系统似乎控制蛋白质合成。在研究与蛋白质合成相关的信号传导事件时，应考虑下游效应物的异质性，蛋白质合成被用作肥大的早期标志物。版权所有（C）2003 S. Karger AG，巴塞尔。
In response to both hemodynamic and neurohumoral changes, the cardiovascular system remodels and this process could contribute to end organ damage. The aim of this study was to determine the early in vivo interactions between 3 systems known to contribute to vascular hypertrophic remodeling, in conduit and resistance arteries. Exogenous angiotensin II, norepinephrine and endothelin 1 administration elevated protein synthesis in the aorta and in small mesenteric arteries. In small arteries, the effect of angiotensin II was blocked by angiotensin II type 1, alpha-adrenergic and endothelin receptor antagonists, while only the alpha-adrenergic and endothelin receptor antagonists inhibited the effect of norepinephrine. Moreover, only the endothelin receptor antagonist significantly blunted the effect of exogenous endothelin on protein synthesis. In the aorta, the stimulation of angiotensin II on protein synthesis was also inhibited by the 3 antagonists. However, only the alpha-adrenoceptor antagonist blunted the response to norepinephrine, and the 3 antagonists prevented the endothelin-induced elevation of protein synthesis. The blood pressure effects of the drugs did not correlate with their capacity to stimulate or inhibit vascular protein synthesis. In conclusion, interactions in the control of protein synthesis are heterogeneous along the vascular tree. In small arteries, the interaction is linear with endothelin as the downstream effector. In the aorta, the local sympathetic nervous system appears to control protein synthesis. The heterogeneity in downstream effectors should be considered in studies investigating signaling events related to protein synthesis, which is used as an early marker of hypertrophy. Copyright (C) 2003 S. Karger AG, Basel.