The impact of statin treatment on diabetic patients.
The impact of statin treatment on diabetic patients.
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他汀类药物治疗对糖尿病患者的影响。
DOI：
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发表时间：
2003
影响因子：
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通讯作者：
H. Koshiyama
中科院分区：
文献类型：
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作者：
H. Koshiyama
二级预防试验的回顾性分析表明，3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂（他汀类药物）可降低糖尿病患者冠心病事件复发的风险。糖尿病个体可能比非糖尿病个体从他汀类药物治疗中获得更大的益处，因为绝对风险更高。现有的数据是有限的，虽然一些随机试验的一级预防糖尿病患者正在进行中。对于糖尿病患者，低密度脂蛋白胆固醇的目标现在被认为是< 100 mg/dl。他汀类药物的多效性作用可能与他汀类药物的抗动脉粥样硬化或其他作用有关。
Retrospective analysis of secondary prevention trials indicates that 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors (statins) reduce the risk of recurrent coronary heart disease events in individuals with diabetes. Diabetic individuals may receive greater benefit from statin treatment than non-diabetic individuals, because of a higher absolute risk. Available data are limited, although several randomized trials of primary prevention with diabetic patients are ongoing. The low-density lipoprotein cholesterol goal is now considered to be < 100 mg/dl for individuals with diabetes. Pleiotropic effects of statins may be involved in anti-atherogenic or other actions of statin.