Anti-neutrophil cytoplasmic antibody in patients with systemic lupus erythematosus is unrelated to clinical features
Anti-neutrophil cytoplasmic antibody in patients with systemic lupus erythematosus is unrelated to clinical features
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DOI：
10.1007/bf02238766
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发表时间：
1997-01-01
影响因子：
3.4
通讯作者：
Hashimoto, K
中科院分区：
文献类型：
--
作者：
Nishiya, K;Chikazawa, H;Hashimoto, K
为探讨系统性红斑狼疮（SLE）患者血清抗中性粒细胞胞浆抗体（ANCA）阳性的发生率、特异性及临床意义，采用间接免疫荧光（IIF）技术和酶联免疫吸附试验（ELISA）检测了31例SLE患者血清ANCA、髓过氧化物酶（MPO）、乳铁蛋白（LF）、组织蛋白酶-G（CTG）和弹性蛋白酶（HLE）作为ANCA的ELISA抗原。13例（42%）SLE患者显示阳性核周，而不是胞浆，ANCA的IIF。31份血清中5份MPO阳性，10份LF阳性，1份CTG阳性，0份HLE阳性。ANCA阳性患者SLE疾病活动指数（SLEDAI）评分高于ANCA阴性患者。ANCA阳性与临床表现或器官受累无相关性。虽然SLE患者的ANCA反映了疾病活动性，但与器官受累无关。
To investigate the incidence, the specificity and clinical significance of positivity for serum anti-neutrophil cytoplasmic antibody (ANCA) in 31 patients with systemic lupus erythematosus (SLE), the indirect immunofluorescence (IIF) technique and enzyme-linked immunosorbent assay (ELISA) were used to measure ANCA, Purified myeloperoxidase (MPO), lactoferrin (LF), cathepsin-G (CTG) and elastase (HLE) served as ANCA antigens for ELISA. Thirteen (42%) of the 31 SLE patients showed positivity for perinuclear, but not cytoplasmic, ANCA by IIF. Five of 31 sera were positive for MPO, 10 for LF, 1 for CTG and 0 for HLE by ELISA. Patients positive for ANCA had a higher score of SLE disease activity index (SLEDAI) than those without ANCA. There was no correlation bet seen ANCA positivity, clinical manifestations, or organic involvement, While the ANCA in patients with SLE reflected disease activity, it was unrelated to organic involvement.