Exercise plus behavioral management in patients with Alzheimer disease - A randomized controlled trial
Exercise plus behavioral management in patients with Alzheimer disease - A randomized controlled trial
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DOI：
10.1001/jama.290.15.2015
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发表时间：
2003-10-15
影响因子：
120.7
通讯作者：
Larson, EB
中科院分区：
文献类型：
--
作者：
Teri, L;Gibbons, LE;Larson, EB
对阿尔茨海默病患者进行背景运动训练，并教照顾者如何管理行为问题，可能有助于减少阿尔茨海默病患者中常见的脆弱和行为障碍。目的确定基于家庭的锻炼计划结合照顾者行为管理技术培训是否可以减少阿尔茨海默病患者的功能依赖和延迟住院时间。设计、设置和患者随机对照试验，于1994年6月至1999年4月进行，对153名符合美国国家神经与传播疾病研究所和中风/阿尔茨海默病及相关疾病协会阿尔茨海默病协会标准的社区患者进行了研究。患者-照顾者之间的干预被随机分配到运动和照顾者培训相结合的方案中，减少阿尔茨海默病残疾(RDAD)或常规医疗护理(RMC)。结果3个月后，RDAD组与常规护理组比较，运动60min/wk以上(优势比[OR]2.82；95%可信区间[CI]1.25~6.39；P<0.05)；P=.01)，限制活动天数较少(OR，3.10；95%CI，1.08-8.95；P
Context Exercise training for patients with Alzheimer disease combined with teaching caregivers how to manage behavioral problems may help decrease the frailty and behavioral impairment that are often prevalent in patients with Alzheimer disease.Objective To determine whether a home-based exercise program combined with caregiver training in behavioral management techniques would reduce functional dependence and delay institutionalization among patients with Alzheimer disease.Design, Setting, and Patients Randomized controlled trial of 153 community-dwelling patients meeting National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer Disease and Related Disorders Association criteria for Alzheimer disease, conducted between June 1994 and April 1999.Interventions Patient-caregiver dyads were randomly assigned to the combined exercise and caregiver training progam, Reducing Disability in Alzheimer Disease (RDAD), or to routine medical care (RMC). The RDAD program was conducted in the patients' home over 3 months.Main Outcome Measures Physical health and function (36-item Short-Form Health Survey's [SF-36] physical functioning and physical role functioning subscales and Sickness Impact Profile's Mobility subscale), and affective status (Hamilton Depression Rating Scale and Cornell Depression Scale for Depression in Dementia).Results At 3 months, in comparison with the routine care patients, more patients in the RDAD group exercised at least 60 min/wk (odds ratio [OR], 2.82; 95% confidence interval [CI], 1.25-6.39; P=.01) and had fewer days of restricted activity (OR, 3.10; 95% Cl, 1.08-8.95; P