A frontotemporoparietal network common to initiating and responding to joint attention bids
A frontotemporoparietal network common to initiating and responding to joint attention bids
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DOI：
10.1016/j.neuroimage.2014.12.041
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发表时间：
2015-03-01
期刊：
影响因子：
5.7
通讯作者：
Woolgar, Alexandra
中科院分区：
文献类型：
--
作者：
Caruana, Nathan;Brock, Jon;Woolgar, Alexandra
共同注意是一种基本的认知能力，支持日常人际关系和沟通。并行分布式处理模型（PDPM）假设，响应（RJA）和启动（IJA）联合注意主要是由后顶叶和额叶区域分别支持。它还认为，这些神经网络在发展过程中整合，支持互动过程中自我和他人注意力表征的并行过程。然而，PDPM的直接证据是有限的，由于缺乏生态有效的实验范式，可以捕捉RJA和IJA。基于现有的互动方法，我们开发了一个虚拟现实模式，参与者在网上互动，完成合作任务。通过包括严格控制的基线条件来消除与非社会任务需求相关的活动，我们能够直接对比RJA和IJA的神经相关性，以确定这些过程是否得到共同大脑区域的支持。RJA和IJA都激活了广泛的额颞顶网络。关键的是，一项联合分析发现，这些区域的一个子集是共同的RJA和IJA。该右侧网络包括额中回（MFG）、额下回（IFG）、颞中回（MTG）、中央前回、后上级颞沟（pSTS）、颞顶连接（TPJ）和楔前叶的背侧部分。在MFG、IFG、TPJ和楔前叶，相对于RJA，在该网络中观察到IJA的额外激活。这是第一个成像研究，直接调查共同的RJA和IJA参与的神经相关性，从而支持一个广泛的综合网络的基础上发起和响应联合注意的平行方面的假设。皇冠版权所有（C）2014由Elsevier Inc.发布。All rights reserved.
Joint attention is a fundamental cognitive ability that supports daily interpersonal relationships and communication. The Parallel Distributed Processing model (PDPM) postulates that responding to (RJA) and initiating (IJA) joint attention are predominantly supported by posterior-parietal and frontal regions respectively. It also argues that these neural networks integrate during development, supporting the parallel processes of self-and other-attention representation during interactions. However, direct evidence for the PDPM is limited due to a lack of ecologically valid experimental paradigms that can capture both RJA and IJA. Building on existing interactive approaches, we developed a virtual reality paradigm where participants engaged in an online interaction to complete a cooperative task. By including tightly controlled baseline conditions to remove activity associated with non-social task demands, we were able to directly contrast the neural correlates of RJA and IJA to determine whether these processes are supported by common brain regions. Both RJA and IJA activated broad frontotemporoparietal networks. Critically, a conjunction analysis identified that a subset of these regions were common to both RJA and IJA. This right-lateralised network included the dorsal portion of the middle frontal gyrus (MFG), inferior frontal gyrus (IFG), middle temporal gyrus (MTG), precentral gyrus, posterior superior temporal sulcus (pSTS), temporoparietal junction (TPJ) and precuneus. Additional activation was observed in this network for IJA relative to RJA at MFG, IFG, TPJ and precuneus. This is the first imaging study to directly investigate the neural correlates common to RJA and IJA engagement, and thus support the assumption that a broad integrated network underlies the parallel aspects of both initiating and responding to joint attention. Crown Copyright (C) 2014 Published by Elsevier Inc. All rights reserved.