Relationship between baseline plasma p-tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults.
Relationship between baseline plasma p-tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults.
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DOI：
10.1002/dad2.12487
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发表时间：
2023-10
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临床前阿尔茨海默病 (AD) 影响很大一部分认知未受损 (CU) 的老年人。目前，基于血液的生物标志物可以非常准确地检测 AD 连续体的早期变化。我们使用基于电化学发光 (ECL) 的检测 (MesoScale Discovery) 在 533 名 CU 老年人中测量了基线血浆磷酸化 tau (p-tau)181。随访持续长达18个月。认知表现评估包括记忆力和认知控制。大脑结构测量包括皮质厚度（包括 AD 磁共振成像 (AD MRI) 特征）和海马体积。在这组 CU 老年人中，基线血浆 p-tau181 水平与认知和大脑结构测量的短期变化无关。此外，基线血浆 p-tau 水平并不影响行为干预（运动或正念）对认知和结构性大脑变化的影响。该 CU 队列的短期随访和健康状况可能限制了血浆 p-tau181 在检测与 AD 病理相关的变化方面的敏感性。
Preclinical Alzheimer's disease (AD) affects a significant proportion of cognitively unimpaired (CU) older adults. Currently, blood‐based biomarkers detect very early changes in the AD continuum with great accuracy. We measured baseline plasma phosphorylated tau (p‐tau)181 using electrochemiluminescence (ECL)‐based assay (MesoScale Discovery) in 533 CU older adults. Follow‐up lasted up to 18 months. Cognitive performance assessment included memory and cognitive control. Structural brain measures included cortical thickness, which includes the AD magnetic resonance imaging (AD MRI) signature, and hippocampal volume. In this cohort of CU older adults, baseline plasma p‐tau181 levels were not associated with short‐term changes in cognition and structural brain measures. Also, baseline plasma p‐tau levels did not influence the effects of behavioral interventions (exercise or mindfulness) on cognitive and structural brain changes. The short follow‐up and healthy status of this CU cohort might have limited the sensitivity of plasma p‐tau181 in detecting changes associated with AD pathology.