Low-threshold mechanoreceptive afferents in the human lingual nerve.
Low-threshold mechanoreceptive afferents in the human lingual nerve.
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人类舌神经中的低阈值机械感受传入。
DOI：
10.1152/jn.1997.77.2.737
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Essick,GK
中科院分区：
文献类型：
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作者：
Trulsson,M;Essick,GK
Trulsson，Mats and Gregory K. Essick。人类舌神经的低阈值机械感受性传入。神经生理学杂志。77：737-748，1997。用经粘膜插入的钨微电极记录了人舌神经的单机械感受性传入神经束内多单位活动和冲动。尼龙丝和钝头玻璃探针用于舌背表面粘膜的机械刺激。在多单位记录的神经支配领域的九个神经束映射。所有的束域包括舌尖，这表明该区域的神经支配密度特别高。33个单一的机械感受性传入的分离和研究。在这些传入神经中，22个的特征在于非常小的粘膜感受野（范围：1-19.6 mm 2;几何平均值：2.4 mm 2），并对极低的机械力（力阈值范围：0.03-2 mN;几何平均值：0.15 mN）作出反应。因此，得出的结论是，这些“浅表”单位终止于舌表面附近。其余11个单元对舌头的大面积探测（>200 mm 2）有反应，并表现出高力阈值（≥4 mN）。得出的结论是，这些“深”单位终止于舌的肌肉质量。14个表层单位被归类为快速适应，类似于人类手部无毛皮肤的快速适应I型传入。快速适应单位的应用程序和删除过程中作出反应，但不是在维护过程中，机械刺激的感受野。观察到两种类型的缓慢适应反应。一种类型（仅2个单位的特征）的特征在于在施加和去除机械刺激期间对力变化的显著敏感性以及在感受野上维持刺激期间的不规则静电放电。相比之下，其他六个单位表现出弱的敏感性，力的变化，一个高度定期的静电放电，和自发活动。因此，这两种类型的缓慢适应单位类似于缓慢适应I和II传入，分别描述了手。所有11个深层单位都在缓慢适应，另外7个单位自发活动。这些单位对机械刺激的应用和去除并不同样敏感，这表明舌肌中至少有两种不同的终止模式。在没有与感受野直接接触的情况下，深层单位可靠地编码关于舌头运动的信息。相反，当舌头移动使感受野与其他口内结构发生物理接触时，浅表单位会做出强烈反应。
Trulsson, Mats and Gregory K. Essick.Low-threshold mechanoreceptive afferents in the human lingual nerve.J. Neurophysiol.77: 737–748, 1997. Intrafascicular multiunit activity and impulses in single mechanoreceptive afferents were recorded from the human lingual nerve with permucosally inserted tungsten microelectrodes. Nylon filaments and blunt glass probes were used for mechanical stimulation of the mucosa of the dorsal surface of the tongue. The innervation territories of nine nerve fascicles were mapped during multiunit recordings. All fascicle fields included the tip of the tongue, suggesting a particularly high innervation density for this area. Thirty-three single mechanoreceptive afferents were isolated and studied. Of these afferents, 22 were characterized by very small mucosal receptive fields (range: 1–19.6 mm2; geometric mean: 2.4 mm2) and responded to extremely low mechanical forces (force threshold range: 0.03–2 mN; geometric mean: 0.15 mN). As such, it was concluded that these “superficial” units terminated near the surface of the tongue. The remaining 11 units responded to probing of large areas of the tongue (>200 mm2) and exhibited high force thresholds (≥4 mN). It was concluded that these “deep” units terminated in the muscle mass of the tongue. Fourteen of the superficial units were classified as rapidly adapting and resembled the fast-adapting type I afferents described for the glabrous skin of the human hand. The rapidly adapting units responded both during the application and removal of, but not during maintenance of, the mechanical stimuli on the receptive field. Two types of slowly adapting responses were observed. One type (characteristic of only 2 units) was characterized by a pronounced sensitivity to force change during the application and removal of the mechanical stimuli and an irregular static discharge during maintenance of the stimulus on the receptive field. In contrast, the other six units exhibited a weak sensitivity to force change, a highly regular static discharge, and spontaneous activity. As such, these two types of slowly adapting units resembled the slowly adapting I and II afferents, respectively, described for the hand. All 11 deep units were slowly adapting, and 7 were, in addition, spontaneously active. The units were not equally sensitive to the application and removal of the mechanical stimuli, suggesting at least two different modes of termination in tongue muscle. The deep units reliably encoded information about tongue movements in the absence of direct contact with the receptive field. In contrast, the superficial units responded vigorously when the tongue was moved to bring the receptive field into physical contact with other intraoral structures.