Are there gender differences in the temperature profile of mice after acute antidepressant administration and exposure to two animal models of depression?
Are there gender differences in the temperature profile of mice after acute antidepressant administration and exposure to two animal models of depression?
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DOI：
10.1016/s0166-4328(00)00351-x
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发表时间：
2001-03-15
影响因子：
2.7
通讯作者：
Bourin, M
中科院分区：
文献类型：
--
作者：
David, DJP;Dhonnchadha, BAN;Bourin, M
许多研究报告了人类抑郁症发病率的性别差异，但很少有人在雌性小鼠身上调查抗抑郁药物效果的行为观察。强迫游泳试验(FST)被广泛用于预测啮齿类动物的抗抑郁活性，尾部悬挂试验(TST)也是如此，后者客观地测量了不动的程度，在最后一项测试中，浸泡在冷水中不会导致体温降低。本研究调查了服用急性抗抑郁药(丙咪嗪和帕罗西汀)和暴露于两种抑郁动物模型后小鼠体温分布的性别差异。在FST中，丙咪嗪和帕罗西汀在雄性小鼠中的活性为32 mg/kg，在雌性小鼠中的活性为8、16和32 mg/kg。给药剂量为16和32 mg/kg时，两种抗抑郁药对雄性小鼠的不动时间均有不同程度的缩短，给药剂量为32 mg/kg时，雌性小鼠的不动时间明显缩短。雄性和雌性小鼠在不动时间上没有显著差异。在FST中，给予丙咪嗪，而不是帕罗西汀，可在较高剂量(32 mg/kg)下降低雄性和雌性小鼠的体温。FST攻击后，各处理组雌、雄小鼠体温均下降。丙咪嗪(雄鼠16和32 mg/kg，雌鼠32 mg/kg)和帕罗西汀(雄鼠4、16和32 mg/kg，雌鼠4~32 mg/kg)可减轻FST引起的体温下降。在TST中，丙咪嗪有降低雄性和雌性小鼠体温的趋势，尽管雌性小鼠只有32 mg/kg剂量的丙咪嗪显著降低体温。帕罗西汀对体温无影响。TST能提高雄性和雌性小鼠的体温。在小鼠中，给予丙咪嗪或帕罗西汀后，FST和TST的性别之间没有差异。这两种测试都可以用来预测抗抑郁剂的活性，因为温度的降低或升高与不动时间的减少没有相关性。(C)2001 Elsevier Science B.V.保留所有权利。
Numerous studies have reported gender differences in the rates of depression in humans, but few behavioural observations of antidepressant drug effects have been investigated in female mice. The forced swimming test (FST) is widely used as a predictor of antidepressant activity in rodents, as is the tail suspension test (TST), where immobility is objectively measured and in this last test, no hypothermia is induced by immersion in cold water. The present study investigated gender differences in the temperature profile of mice after acute antidepressant administration (imipramine and paroxetine) and exposure to two animal models of depression. Imipramine and paroxetine were active at 32 mg/kg in male mice in the FST, whereas they were active at 8, 16 and 32 mg/kg in female mice. Tn the TST, for both antidepressants immobility duration was reduced at a dose of 16 and 32 mg/kg in male mice and at 32 mg/kg in female mice. No significant difference was observed between male and female mice for immobility duration. Imipramine administration, but not paroxetine, decreased the temperature at the higher dose (32 mg/kg) in male and female mice in the FST. The body temperature was reduced in male and female mice for all treatment groups after FST challenge. Imipramine (16 and 32 mg/kg in male and 32 mg/kg in female mice), paroxetine (4, 16 and 32 mg/kg in male and 4 to 32 mg/kg in female mice) attenuated the reduction in temperature due to the FST. In the TST, imipramine tends to decrease the temperature in male and female mice, even though only imipramine at a dose of 32 mg/kg in female mice significantly decreases the temperature. Paroxetine had no effect on temperature. The TST enhanced the body temperature in male and female mice. In mice, there was no difference between the sexes after imipramine or paroxetine administration in the FST and TST. Both tests can be used to predict the activity of antidepressants as the decrease or enhancement of temperature is not correlated with a reduction in immobility duration. (C) 2001 Elsevier Science B.V. All rights reserved.