Vitamin D Receptor Gene Polymorphisms Are Associated with Abdominal Visceral Adipose Tissue Volume and Serum Adipokine Concentrations but Not with Body Mass Index or Waist Circumference in African Americans: The Jackson Heart Study
Vitamin D Receptor Gene Polymorphisms Are Associated with Abdominal Visceral Adipose Tissue Volume and Serum Adipokine Concentrations but Not with Body Mass Index or Waist Circumference in African Americans: The Jackson Heart Study
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DOI：
10.3945/jn.116.229963
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发表时间：
2016-08-01
影响因子：
4.2
通讯作者：
Davis, Sharon K.
中科院分区：
文献类型：
--
作者：
Khan, Rumana J.;Riestra, Pia;Davis, Sharon K.
背景：维生素D的生物学作用是通过维生素D受体（VDR）介导的。VDR基因中的单核苷酸多态性（SNP）以前与肥胖性状相关。然而，据我们所知，很少有研究包括直接测量肥胖和脂肪因子浓度。目的：我们研究了VDR基因中标记SNP与多种肥胖指标的相关性，包括腰围（WC），体重指数（BMI），体脂百分比，皮下和内脏脂肪组织（VAT）体积，和血清脂肪因子（脂联素和瘦素）浓度在成年非裔美国人（AAs）。方法：数据来自3020名参与者（61.9%的妇女，平均年龄，54.6岁），从杰克逊心脏研究用于此分析。45个标签SNPs的选择与使用的基因型数据从国际HapMap项目。我们使用线性回归来检验估算的VDR SNPs与每个性状的相关性，校正年龄、性别、教育状况、体力活动、吸烟、饮酒、血清维生素D浓度、欧洲血统和多重检验。结果：SNP rs 4328262的G等位基因在多重检验校正后仍然与VAT体积增加相关（β = 45.7; P < 0.001）。另一个SNP（rs 11574070）的A等位基因名义上与体脂百分比相关（β = 0.96; P = 0.002）。所分析的VDR SNP均未显示与WC或BMI有任何联系。rs 2228570的A等位基因（β = 0.08; P = 0.001）男性和rs 2853563的T等位基因经多重检验校正后，女性的血清脂联素水平与血清脂联素水平呈正相关（β = 0.04; P < 0.001）。虽然我们没有发现人体测量的任何关联，我们确实观察到VDR变异与血清脂肪因子和代谢活性更高的脂肪，VAT的关联。因此，我们的研究结果表明，VDR变异体在调节脂肪组织活性和脂肪酸之间的可能作用。
Background: The biological actions of vitamin D are mediated through the vitamin D receptor (VDR). Single-nucleotide polymorphisms (SNPs) in the VDR gene have been previously associated with adiposity traits. However, to our knowledge, few studies have included direct measures of adiposity and adipokine concentrations.Objective: We examined the association of tagging SNPs in the VDR gene with multiple adiposity measures, including waist circumference (WC), body mass index (BMI), body fat percentage, subcutaneous and visceral adipose tissue (VAT) volume, and serum adipokine (adiponectin and leptin) concentrations in adult African Americans (AAs).Methods: Data from 3020 participants (61.9% women; mean age, 54.6 y) from the Jackson Heart Study were used for this analysis. Forty-five tag SNPs were chosen with the use of genotype data from the International HapMap project. We used linear regression to test the associations of imputed VDR SNPs with each of the traits, adjusted for age, sex, educational status, physical activity, smoking, alcohol intake, serum vitamin D concentration, European ancestry, and multiple testing.Results: The G allele of the SNP rs4328262 remained associated with increased VAT volume after multiple testing correction (beta = 45.7; P < 0.001). The A allele of another SNP (rs11574070) was nominally associated with body fat percentage (beta = 0.96; P = 0.002). None of the VDR SNPs analyzed showed any link with WC or BMI. The A allele of rs2228570 (beta = 0.08; P = 0.001) for men and the T allele of rs2853563 (beta = 0.04; P < 0.001) for women remained positively associated with serum adiponectin concentrations after multiple testing correction.Conclusion: Although we did not find any association for anthropometric measures, we did observe associations of VDR variants with serum adipokines and with the more metabolically active fat, VAT. Therefore, our findings demonstrate a possible role of VDR variants in regulating adipose tissue activity and adiposity among AAs.