Multispectral optical tweezers for molecular diagnostics of single biological cells
Multispectral optical tweezers for molecular diagnostics of single biological cells
复制标题
用于单个生物细胞分子诊断的多光谱光镊
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
M. Richardson
中科院分区：
文献类型：
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作者：
C. Butler;S. Fardad;Alex Sincore;M. Vangheluwe;M. Baudelet;M. Richardson
单生物细胞的光学捕获已经成为一种用于控制和研究单细胞与其环境的基本行为而没有“多体”干扰的成熟技术。这种通过激光光谱学利用“捕获”光束或次级光束进行光学诊断（包括用于分子诊断的拉曼和荧光）的仪器的开发仍在进行中。本文介绍了一种结合生物细胞拉曼和荧光诊断的模块化多光谱成像光镊的研制。
Optical trapping of single biological cells has become an established technique for controlling and studying fundamental behavior of single cells with their environment without having "many-body" interference. The development of such an instrument for optical diagnostics (including Raman and fluorescence for molecular diagnostics) via laser spectroscopy with either the "trapping" beam or secondary beams is still in progress. This paper shows the development of modular multi-spectral imaging optical tweezers combining Raman and Fluorescence diagnostics of biological cells.