Redox-active metal complexes for imaging hypoxic tissues: structure-activity relationships in copper(II) bis(thiosemicarbazone) complexes
Redox-active metal complexes for imaging hypoxic tissues: structure-activity relationships in copper(II) bis(thiosemicarbazone) complexes
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DOI：
10.1039/a805957h
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发表时间：
1998-11-21
影响因子：
4.9
通讯作者：
Blower, PJ
中科院分区：
文献类型：
--
作者：
Dearling, JLJ;Lewis, JS;Blower, PJ
铜(II)双(缩氨基硫脲)络合物的还原电位和亲脂性可以通过二酮主链和配体N-末端的烷基化来独立控制，从而允许优化对缺氧组织具有强烈选择性的放射性药物。
Reduction potential and lipophilicity of the copper(II) bis(thiosemicarbazone) complexes can be independently controlled by alkylation in the diketone backbone and the N-termini of the ligand, allowing optimisation of radiopharmaceuticals strongly selective for hypoxic tissues.