Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract.
Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract.
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发表时间：
1989
期刊：
影响因子：
8
通讯作者：
X. Zhang;E. Silva;D. Gershenson;M. Hung
中科院分区：
文献类型：
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作者：
X. Zhang;E. Silva;D. Gershenson;M. Hung
在人类基因组中有两个与v-er B B癌基因相关的基因。c-er B B-1基因编码表皮生长因子受体（EGF-r），c-er B B-2/neu基因编码与EGF-r非常相似但不同的受体样蛋白。对15例卵巢癌组织进行Southern杂交分析，发现3例卵巢癌组织中有c-er B B-2/neu基因扩增。c-er B B-1/EGF-r基因未扩增。在1例子宫内膜腺癌中，c-er B B-1/EGF-r基因5'端发生重排。重排的c-er B B-1/EGF-r基因的基因组结构类似于在鸡v-er B B癌基因中发现的那些，其产生EGF-r的截短形式。结果提示c-er B B-2/neu基因扩增可能在卵巢癌的发病机制中起一定作用。此外，子宫内膜腺癌中的人c-er B B-1/EGF-r基因可能通过与鸡v-er B B癌基因中类似的机制被激活。
There are two genes related to the v-erb B oncogene in the human genome. The c-erb B-1 gene encodes the epidermal growth factor receptor (EGF-r), and the c-erb B-2/neu gene encodes a receptor-like protein very similar to, but distinct from the EGF-r. Southern blot analysis of DNAs from 15 fresh human ovarian carcinomas showed that the c-erb B-2/neu gene was amplified in 3 tumors. The c-erb B-1/EGF-r gene was not amplified. However, in one case of adenocarcinoma of uterine endometrium, the c-erb B-1/EGF-r was found to be rearranged in the 5' region of this gene. The genomic structure of the rearranged c-erb B-1/EGF-r gene is similar to those found in the chicken v-erb B oncogene, which produces a truncated form of the EGF-r. The results suggest that amplification of the c-erb B-2/neu gene may play a role in the pathogenesis of ovarian carcinoma. Further, the human c-erb B-1/EGF-r gene in adenocarcinoma of uterine endometrium may be activated by a similar mechanism as that in the chicken v-erb B oncogene.