Non-linear dynamic analysis of hemodynamic parameters in an undulation type artificial heart system.
Non-linear dynamic analysis of hemodynamic parameters in an undulation type artificial heart system.
复制标题
波动型人工心脏系统血流动力学参数的非线性动态分析。
DOI：
10.1016/s0753-3322(02)00318-9
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
S. Nitta
中科院分区：
文献类型：
--
作者：
T. Yambe;Y. Abe;T. Isoyama;K. Tabayashi;S. Nanka;K. Imachi;S. Nitta
波动泵全人工心脏（UPTAH）是一种独特的全人工心脏植入物（TAH），使用波动泵，是一种连续的血液流动泵。为了评价自主神经调节循环系统的功能，我们应用混沌和分形理论等非线性数学分析技术，对UPTAH动物实验中的血流动力学参数进行了分析。成年母山羊用于UPTAH植入。在体外循环下用UPTAH替代天然心脏。在术后第5 - 7天应用基于传导和动脉压的控制方法（1/R控制），因为诊断出体外循环循环的影响终止。在数据记录仪上记录血流动力学参数，并进行非线性数学分析。为了定量评价确定性混沌的特征--奇异吸引子，进行了分形维数分析。结果表明，血液动力学参数在时间轴上波动，并表现出分形特征，这被认为是确定性混沌的特征。重构的血流动力学吸引子根据山羊的情况变化表现出不同的行为。这些结果表明，非线性动力学分析可能是有用的，在监测人工心脏循环中的循环调节系统。All rights reserved.
Undulation pump total artificial heart (UPTAH) is a unique total artificial heart implant (TAH) using an undulation pump that is a continuous blood flow pump. To evaluate the autonomic nerve function mediating the circulation system, we analyzed the hemodynamic parameters during animal experiments with UPTAH using the non-linear mathematical analyzing technique, including chaos and fractal theory. Adult female goats were used for the implantation of UPTAH. The natural heart was replaced with UPTAH under extra-corporal circulation. The conductance-and arterial pressure-based control method (1/R control) was applied on the 5th to 7th post-operative day as the influences of the cardiopulmonary bypass circulation were diagnosed to be terminated. Hemodynamic parameters were recorded on the data recorder, and non-linear mathematical analysis was performed. For the quantitative evaluation of the strange attractor, which was the characteristics of the deterministic chaos, the fractal dimension analysis was carried out. As a result, hemodynamic parameters fluctuated on the time axis and showed fractal characteristics, which were thought to be the characteristics of the deterministic chaos. The reconstructed attractor of the hemodynamics showed various behaviors according to changes in the situation of the goats. These results suggest that non-linear dynamical analysis might be useful in monitoring the circulatory regulatory system in artificial heart circulation.© 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.