5-HT1A receptor agonists, xaliproden and tandospirone, inhibit the increase in the number of cutaneous mast cells involved in the exacerbation of mechanical allodynia in oxaliplatin-treated mice
5-HT1A receptor agonists, xaliproden and tandospirone, inhibit the increase in the number of cutaneous mast cells involved in the exacerbation of mechanical allodynia in oxaliplatin-treated mice
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DOI：
10.1016/j.jphs.2016.07.008
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发表时间：
2016-08-01
影响因子：
3.5
通讯作者：
Kuraishi, Yasushi
中科院分区：
文献类型：
--
作者：
Andoh, Tsugunobu;Sakamoto, Ayumi;Kuraishi, Yasushi
奥沙利铂引起周围神经病变是一种主要的剂量限制性副作用，并且控制这种神经病变是困难的。本研究旨在探讨预防性重复给予 5-HT1A 受体激动剂是否可以抑制奥沙利铂诱导的小鼠机械性异常性疼痛。重复给予 5-HT1A 受体激动剂（xaliproden 和 tandospirone）可抑制单次腹膜内注射奥沙利铂引起的机械异常性疼痛。这些激动剂还抑制奥沙利铂诱导的肥大细胞迁移，肥大细胞迁移参与机械异常性疼痛的诱导。这些结果表明，预防性重复施用 5-HT1A 受体激动剂可通过抑制皮肤肥大细胞迁移来减轻奥沙利铂诱导的机械异常性疼痛。 (C) 2016 年作者。由 Elsevier B.V. 代表日本药理学会制作和主办。
Oxaliplatin causes peripheral neuropathy as a major dose-limiting side effect, and the control of this neuropathy is difficult. This study was designed to investigate whether prophylactic repetitive administration of 5-HT1A receptor agonists inhibits oxaliplatin-induced mechanical allodynia in mice. Repetitive administration of 5-HT1A receptor agonists (xaliproden and tandospirone) inhibited mechanical allodynia induced by a single intraperitoneal injection of oxaliplatin. These agonists also inhibited oxaliplatin-induced mast cell migration, which is involved in the induction of mechanical allodynia. These results suggest that the prophylactic repetitive administration of 5-HT1A receptor agonists attenuates oxaliplatin-induced mechanical allodynia by inhibiting the cutaneous mast cell migration. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.