ERP indicators of disturbed attention in mild closed head injury: a frontal lobe syndrome?
ERP indicators of disturbed attention in mild closed head injury: a frontal lobe syndrome?
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轻度闭合性颅脑损伤中注意力紊乱的 ERP 指标：额叶综合征？
DOI：
10.1111/1469-8986.3660802
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发表时间：
1999
期刊：
影响因子：
3.7
通讯作者：
K. Sundet
中科院分区：
文献类型：
--
作者：
A. Solbakk;I. Reinvang;Christopher S Nielsen;K. Sundet
本研究的目的是检验这一假设，即注意力分散是轻度闭合性颅脑损伤（MHI）的一个基本特征。还调查了MHI中的认知症状是由于轻度额颞叶损伤所致的说法。在MHI患者（N = 15）、经证实的额叶损伤患者（N = 10）和健康对照组（N = 13）中研究了认知事件相关电位（ERP）、双耳分听范式中对目标刺激的准确性和反应时间以及神经心理学测试结果。研究了反映目标检测（N2，P3b）和持续选择性注意（加工负性）的信息加工。MHI和额叶患者在行为测量上没有差异，除了MHI组在ERP任务中对目标刺激的反应时间显着延长。与对照组相比，两组患者的ERP都有异常，但他们的ERP模式在重要方面有所不同。与预期相反，MHI患者的ERP异常最多。他们表现出显着较小的N2和Nd振幅比额叶患者和对照组，表明介导的认知机制是不等同的MHI和额叶损伤。这些数据表明，MHI患者分配较少的处理资源的任务比对照组或额叶损伤的患者。
The purpose of the study was to examine the hypothesis that distractibility is a fundamental characteristic of mild closed head injury (MHI). The claim that cognitive symptoms in MHI are due to a mild type of frontotemporal injury was also investigated. Cognitive event-related potentials (ERPs), accuracy and reaction time to target stimuli in a dichotic listening paradigm, and neuropsychological test results were studied in patients with MHI (N = 15), patients with verified frontal lobe damage (N = 10), and healthy controls (N = 13). Information processing reflecting target detection (N2, P3b) and sustained selective attention (processing negativity) was studied. The MHI and frontal patients did not differ on behavioral measures, except that the MHI group had significantly longer reaction times to target stimuli in the ERP task. Both patient groups had deviant ERPs compared with controls, but their ERP patterns differed in important respects. Contrary to expectations, the MHI patients had the most abnormal ERPs. They showed significantly smaller N2 and Nd amplitudes than frontal patients and controls, indicating that the mediating cognitive mechanisms were not equivalent in MHI and frontal injury. The data suggest that MHI patients allocated less processing resources to the task than either the control subjects or the patients with frontal lobe damage.