SELF-TOLERANCE ELIMINATES T-CELLS SPECIFIC FOR MLS-MODIFIED PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
SELF-TOLERANCE ELIMINATES T-CELLS SPECIFIC FOR MLS-MODIFIED PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
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DOI：
10.1038/332035a0
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发表时间：
1988-03-03
期刊：
影响因子：
64.8
通讯作者：
MARRACK, PC
中科院分区：
文献类型：
--
作者：
KAPPLER, JW;STAERZ, U;MARRACK, PC
在小鼠中，Mlsalocus的产物是一种不寻常的抗原，能够与主要组织相容性位点（MHC）的某些产物相互作用，形成大部分t细胞α/β受体库的配体，包括几乎所有使用Vβ8.1的受体。在T细胞发育过程中，Mlsa/ MHC的存在导致表达v β8.1的T细胞缺失，这证明了克隆缺失在建立对自身抗原的耐受性中的重要性。
In mice the product of the Mlsalocus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell α/β receptor repertoire, including nearly all receptors that use Vβ8.1. The presence of Mlsa/ MHC during T-cell development results in the deletion of T cells that express Vβ8.1documenting the importance of clonal deletion in establishing tolerance to self antigens.