Exploring a route to a selective and sensitive portable system for explosive detection- swab spray ionisation coupled to of high-field assisted waveform ion mobility spectrometry (FAIMS).
Exploring a route to a selective and sensitive portable system for explosive detection- swab spray ionisation coupled to of high-field assisted waveform ion mobility spectrometry (FAIMS).
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DOI：
10.1016/j.fsisyn.2019.07.009
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Bailey, M J
中科院分区：
文献类型：
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作者：
Costa, C;van Es, E M;Bailey, M J
纸喷雾质谱法是一种快速灵敏的爆炸物检测工具，但迄今为止仅使用高分辨率质谱法进行了证明，这对于许多实际应用来说成本太高。在这里，我们探讨了纸喷雾的潜力，在现场应用中实施便携式质谱。这包括：（a）用擦拭材料（我们称之为“擦拭喷雾”）取代纸质基底，以便与标准收集材料兼容;（B）从表面收集爆炸物;（c）探索± 0.5 m/z窗口内的干扰;（d）演示使用高场辅助波形离子迁移谱仪提高选择性。我们表明，纸和Nomex是可行的收集材料，与Nomex提供更清洁的光谱，因此更大的潜力与便携式质谱仪集成。我们表明，敏感的检测使用拭子喷雾将需要一个质谱仪的质量分辨率为4000或更高。我们表明，通过耦合拭子喷雾电离源与FAIMS，它是可能的，以减少背景干扰，从而促进使用低分辨率（如四极杆）质谱仪。
Paper spray mass spectrometry is a rapid and sensitive tool for explosives detection but has so far only been demonstrated using high resolution mass spectrometry, which bears too high a cost for many practical applications. Here we explore the potential for paper spray to be implemented in field applications with portable mass spectrometry. This involved (a) replacing the paper substrate with a swabbing material (which we call "swab spray") for compatibility with standard collection materials; (b) collection of explosives from surfaces; (c) an exploration of interferences within a ± 0.5 m/z window; and (d) demonstration of the use of high-field assisted waveform ion mobility spectrometer (FAIMS) for enhanced selectivity. We show that paper and Nomex are viable collection materials, with Nomex providing cleaner spectra and therefore greater potential for integration with portable mass spectrometers. We show that sensitive detection using swab spray will require a mass spectrometer with a mass resolving power of 4000 or more. We show that by coupling the swab spray ionisation source with FAIMS, it is possible to reduce background interferences, thereby facilitating the use of a low resolving power (e.g. quadrupole) mass spectrometer.