Oxygen transport studies of normal and sickle erythrocyte suspensions in artificial capillaries.
Oxygen transport studies of normal and sickle erythrocyte suspensions in artificial capillaries.
复制标题
人工毛细血管中正常和镰状红细胞悬浮液的氧输送研究。
DOI：
10.1007/978-1-4684-5188-7_5
复制
发表时间：
1986
影响因子：
--
通讯作者：
Hellums,JD
中科院分区：
文献类型：
--
作者：
Stathopoulos,NA;Hellums,JD
Oxygen transport from normal and sickle erythrocytes was studied under known and caref'. llly controlled condi tio1'1s simuliiting the microcirculation. Oxygenated erythrocyte suspensions became deoxygenated as they traversed silicone rubber capUlaries of 27/J rn diameter. Oxygen saturation values of the flowing erythrocyte suspensions were measured at several axial posi. tions along the capillary by use of a microspectrophotometric technique. Oxygen saturation decreased with increasing distance from the entrance of the ciipUlary and VIas strongly influenced by the flow rate. Under the same hematocrit and flow conditions, the rate of oxygen saturation decrease was significantly higher for the sickle cells than for normal c~ lls. Sickle cells would be expected to have a higher diffusional resistance to oxygen transport than that of normal cells. However, the lower oxygen affinity of the sickle cells tends to increase the oxygen delivery rate. The difference in oxygen affinity appears to account for the difference in oxygen delivery rates between normal and sickle cells.
