Associations of PER3 and RORA Circadian Gene Polymorphisms and Depressive Symptoms in Older Adults
Associations of PER3 and RORA Circadian Gene Polymorphisms and Depressive Symptoms in Older Adults
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DOI：
10.1016/j.jagp.2015.03.002
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发表时间：
2015-10-01
影响因子：
7.2
通讯作者：
Tranah, Gregory J.
中科院分区：
文献类型：
--
作者：
Maglione, Jeanne E.;Nievergelt, Caroline M.;Tranah, Gregory J.
抑郁症状在老年人中很常见，并与不良预后相关。尽管昼夜节律基因与抑郁症有关，但昼夜节律基因与老年人抑郁症状之间的关系尚不清楚。方法：在男性骨质疏松性骨折研究（mrs, N = 270，年龄：76.58 +/- 5.61岁）和女性骨质疏松性骨折研究（SOF, N = 1740, 84.05 +/- 3.53岁）两个基于人群的队列中，对代表30个候选昼夜节律基因的529个单核苷酸多态性（snp）进行了横断面遗传关联研究，并进行了荟萃分析。抑郁症状用老年抑郁量表进行评估，将参与者分为无少量症状（0-2）和部分抑郁症状（> - 6）。结果：我们发现PER3内含子SNP rs12137927与SOF样本中报告“某些抑郁症状”的几率降低（优势比[OR]: 0.61, 95%可信区间[CI]: 0.48-0.78, df = 1, Wald chi(2) = -4.04, p = 0.000054）和meta分析（OR: 0.61, CI: 0.48-0.78, z = -4.04, p = 0.000054）以及PER3内含子SNP rs228644 （OR: 0.74, CI: 0.63-0.86, z = 3.82, p = 0.00013）与rs228682 （OR: 0.00013）之间存在符合多项显著性检验标准的关联。0.74, CI: 0.86-0.63, z = 3.81, p = 0.00014)，在荟萃分析中报告“一些抑郁症状”的几率比认可没有抑郁症状的几率低。RORA内含子SNP rs11632098与男性报告“多种抑郁症状”的几率较高相关（OR: 2.16, CI: 1.45-3.23, df = 1, Wald chi(2) = 3.76, p = 0.000168）。在荟萃分析中，相关性减弱，名义上显著（OR: 1.63, CI: 1.24-2.16, z = 3.45, p = 0.00056）。结论：PER3和RORA可能在老年人抑郁症状的发展中起重要作用。
Depressive symptoms are common in older adults and associated with poor outcomes. Although circadian genes have been implicated in depression, the relationship between circadian genes and depressive symptoms in older adults is unclear. Methods: A cross-sectional genetic association study of 529 single nucleotide polymorphisms (SNPs) representing 30 candidate circadian genes was performed in two population-based cohorts: the Osteoporotic Fractures in Men Study (MrOS; N = 270, age: 76.58 +/- 5.61 years) and the Study of Osteoporotic Fractures (SOF) in women (N = 1740, 84.05 +/- 3.53 years) and a meta-analysis was performed. Depressive symptoms were assessed with the Geriatric Depression Scale categorizing participants as having none-few symptoms (0-2), some depressive symptoms (>2 to = 6). Results: We found associations meeting multiple testing criteria for significance between the PER3 intronic SNP rs12137927 and decreased odds of reporting "some depressive symptoms" in the SOF sample (odds ratio [OR]: 0.61, 95% confidence interval [CI]: 0.48-0.78, df = 1, Wald chi(2) = -4.04, p = 0.000054) and the meta-analysis (OR: 0.61, CI: 0.48-0.78, z = -4.04, p = 0.000054) and between the PER3 intronic SNPs rs228644 (OR: 0.74, CI: 0.63-0.86, z = 3.82, p = 0.00013) and rs228682 (OR: 0.74, CI: 0.86-0.63, z = 3.81, p = 0.00014) and decreased odds of reporting "some depressive symptoms" in the meta-analysis compared to endorsing none-few depressive symptoms. The RORA intronic SNP rs11632098 was associated with greater odds of reporting "many depressive symptoms" (OR: 2.16, CI: 1.45-3.23, df = 1, Wald chi(2) = 3.76, p = 0.000168) in the men. In the meta-analysis the association was attenuated and nominally significant (OR: 1.63, CI: 1.24-2.16, z = 3.45, p = 0.00056). Conclusion: PER3 and RORA may play important roles in the development of depressive symptoms in older adults.