Olfactory reciprocal synapses: Dendritic signaling in the CNS
Olfactory reciprocal synapses: Dendritic signaling in the CNS
复制标题
DOI：
10.1016/s0896-6273(00)81013-2
复制
发表时间：
1998-04-01
期刊：
影响因子：
16.2
通讯作者：
Strowbridge, BW
中科院分区：
文献类型：
--
作者：
Isaacson, JS;Strowbridge, BW
嗅球树突之间的突触传递被认为在嗅觉信息的处理中发挥着重要作用。二尖瓣细胞树突释放的谷氨酸会兴奋颗粒细胞的树突，进而介导 GABA 能树突抑制作用回到二尖瓣树突上。我们研究了大鼠嗅球切片中控制相互树突传递的机制。我们发现 NMDA 受体在这种树突抑制中发挥着关键作用。与纯突触一样，快速神经递质的树突释放依赖于 N 型和 P/Q 型钙通道。树突传输的幅度与树突钙流入成正比。此外，成对二尖瓣细胞的记录表明，树突突触可以独立于轴突动作电位介导侧向抑制。
Synaptic transmission between dendrites in the olfactory bulb is thought to play a major role in the processing of olfactory information. Glutamate released from mitral cell dendrites excites the dendrites of granule cells, which in turn mediate GABAergic dendrodendritic inhibition back onto mitral dendrites. We examined the mechanisms governing reciprocal dendritic transmission in rat olfactory bulb slices. We find that NMDA receptors play a critical role in this dendrodendritic inhibition. As with axenic synapses, the dendritic release of fast neurotransmitters relies on N- and P/Q-type calcium channels. The magnitude of dendrodendritic transmission is directly proportional to dendritic calcium influx. Furthermore, recordings from pairs of mitral cells show that dendrodendritic synapses can mediate lateral inhibition independently of axonal action potentials.