Temporal trends of esophageal cancer during 1995-2004 in Nanao Island, an extremely high-risk area in China
Temporal trends of esophageal cancer during 1995-2004 in Nanao Island, an extremely high-risk area in China
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我国食管癌高发区七尾岛1995-2004年食管癌发病时间变化趋势
DOI：
10.1007/s10654-006-9086-x
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发表时间：
2007-01-01
影响因子：
13.6
通讯作者：
Gao, Yu-Xia
中科院分区：
文献类型：
--
作者：
Su, Min;Liu, Min;Gao, Yu-Xia
本研究目的在探讨南海相对偏远的南尾岛7万名居民的时间性恶性肿瘤发病率。收集1995 - 2004年南尾肿瘤登记中心恶性肿瘤病例资料，采用SPSS 10.0软件进行统计分析。评估肿瘤发病病例、粗发病率、年龄标准化发病率、性别分布和时间趋势。共发现1450例新癌症病例（990例男性和460例女性）。恶性肿瘤年平均年龄标化发病率（ASR）为208.18/10万。男女十大癌症每10万人口的年龄标准化发病率分别为食道癌（EC）74.47、贲门癌（CC）34.81、肝癌25.66、肺癌26.01、胃癌18.52、鼻咽癌4.45、乳腺癌3.91、结肠/直肠癌为2.53，膀胱癌为2.45，胰腺癌为1.92。这十种癌症占所有癌症病例的93%，其中EC和CC最常见，占总病例的52%。南尾岛1995~2004年食道癌、肝癌、肺癌、乳癌、鼻咽癌、大肠癌的发病率呈上升趋势。1995 - 2004年期间，南尾岛的EC ASR令人震惊，男性为72 - 150/10万，女性为26 - 64/10万。南尾人群的EC发病率是世界上最高的，这表明有潜在的遗传和/或环境因素影响这一特定人群。
The purpose of our study was to investigate the temporal malignant tumor incidence rates among the 70,000 residents at the relatively isolated Nanao Island in South China Sea. The data on all malignant tumor cases from Nanao Cancer Registry during 1995-2004 were coded, computerized, and analyzed using the software SPSS10.0. The tumor incident cases, crude incident rate, age-standardized incidence rate, their sex distribution and temporal trend were assessed. A total of 1450 new cancer cases (990 males and 460 females) were identified. The annual average age-standardized incidence rate (ASR) of malignant tumors was 208.18/100,000. The age-standardized incidence rate of the ten leading cancers in both sexes combined per 100,000 population were 74.47 for esophageal cancer (EC), 34.81 for cardiac cancer (CC), 25.66 for liver cancer, 26.01 for lung cancer, 18.52 for stomach cancer, 4.45 for nasopharyngeal cancer, 3.91 for breast cancer, 2.53 for colon/rectum cancer, 2.45 for bladder cancer and 1.92 for pancreatic cancer. These ten types of cancers make up to 93% of all cancer cases, with EC and CC being the most prevalent and making up 52% of the total cases. The incidence rates of esophagus, liver, lung, breast, nasopharyngeal, and colon/rectum cancers showed increasing trends during the period from 1995 to 2004 in Nanao Island. Astounding the EC ASR were 72-150/100,000 among male and 26-64/100,000 among female in Nanao Island during 1995-2004. The EC incidence rate in Nanao population is among the highest across the world, which suggests that there are potential genetic and/or environmental factors affecting this particular population.