Non-myelinated C-fibers, but not myelinated A-fibers, elongate into the epidermis in dry skin with itch
Non-myelinated C-fibers, but not myelinated A-fibers, elongate into the epidermis in dry skin with itch
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DOI：
10.1016/j.neulet.2018.02.034
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发表时间：
2018-04-13
影响因子：
2.5
通讯作者：
Kuraishi, Yasushi
中科院分区：
文献类型：
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作者：
Andoh, Tsugunobu;Asakawa, Yuta;Kuraishi, Yasushi
皮肤瘙痒和干燥的慢性皮肤病表现为周围神经纤维进入表皮的伸长增加。然而，这些细长的神经纤维的特征仍然不清楚。因此，我们利用干性皮肤瘙痒小鼠模型研究了细长神经纤维的特性。在这个用丙酮/乙醚混合物和水重复处理的小鼠模型中，角质层水分含量减少，而自发抓挠和表皮增生增加。此外，治疗组小鼠皮肤中P物质(SP)和降钙素基因相关肽(CGRP)免疫反应神经纤维(C纤维)的数量较未治疗对照组增加。然而，在处理的小鼠的表皮中没有检测到神经丝200免疫反应神经纤维(A纤维)。这些结果表明，细长的表皮周围神经纤维含有含SP/CGRP的C-纤维，但不含A-纤维。因此，这些纤维可能参与了干性皮肤瘙痒的诱导。
Chronic skin diseases with itch and dry skin show increased peripheral nerve fiber elongation into the epidermis. However, the characteristics of the elongated nerve fibers remain unclear. Therefore, we investigated the characteristics of the elongated nerve fibers using a dry skin mouse model with itch. In this mouse model, prepared via repetitive treatments with an acetone/ether mixture and water, the stratum corneum water content was decreased, whereas spontaneous scratching and epidermal hyperplasia were increased. In addition, the number of substance P (SP)- and calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers (C-fibers) was increased in the epidermis of treated mice compared to that in non-treated control mice. However, neurofilament 200-immunoreactive nerve fibers (A-fibers) were not detected in the epidermis of treated mice. These results suggest that the elongated epidermal peripheral nerve fibers comprise SP/CGRP-containing C-fibers but not A-fibers. Thus, these fibers may be involved in the induction of dry skin pruritus.