Molecular distinction of consecutive molar pregnancies
Molecular distinction of consecutive molar pregnancies
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连续葡萄胎妊娠的分子特征
DOI：
10.1097/aog.0b013e318205636b
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发表时间：
2011
期刊：
影响因子：
7.2
通讯作者：
and Shozu M
中科院分区：
文献类型：
--
作者：
Usui H;Kaku H;Kihara M;and Shozu M
背景：这可能是很难区分的连续发生两个独立的摩尔妊娠后，最初的摩尔妊娠滋养细胞肿瘤，特别是当它们之间的时间间隔short.CASE：一个25岁的女人谁有一个完整的葡萄胎6个月前提出了6周的历史继发性闭经。血清人绒毛膜促性腺激素升高至19，857微国际单位/mL，未显示孕囊。进行了扩张和刮除术。病理检查发现少量绒毛水肿，符合完全性葡萄胎。短串联重复序列多态性分析显示，第一和第二完全性葡萄胎的磨牙组织是不同的遗传起源。结论：基因分型有助于鉴别复发性葡萄胎和可疑的妊娠滋养细胞肿瘤，基因分型可以确诊两次连续妊娠中独立的葡萄胎妊娠。
BACKGROUND:It may be difficult to differentiate the consecutive occurrence of two independent molar pregnancies from gestational trophoblastic neoplasia after the initial molar pregnancy, especially when the interval between them is short.CASE:A 25-year-woman who had had a complete hydatidiform mole 6 months earlier presented with a 6-week history of secondary amenorrhea. Serum human chorionic gonadotropin had increased to 19,857 micro-international units/mL, with no gestational sac demonstrated. Dilation and curettage was performed. Pathologic examination identified a tiny amount of hydropic villi compatible with complete hydatidiform mole. Analysis of short tandem repeat polymorphisms revealed that the molar tissues of the first and second complete hydatidiform moles were of different genetic origin. The patient went into remission spontaneously without chemotherapy.CONCLUSION:Genetic profiling was useful to discriminate a recurrent mole from suspected gestational trophoblastic neoplasia.Genotype profiling can confirm the diagnosis of independent molar pregnancies in two closely consecutive pregnancies.