REDUCED-SIZE OF CORPUS-CALLOSUM IN AUTISM
REDUCED-SIZE OF CORPUS-CALLOSUM IN AUTISM
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DOI：
10.1001/archneur.1995.00540320070014
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发表时间：
1995-08-01
影响因子：
--
通讯作者：
SAITOH, O
中科院分区：
文献类型：
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作者：
EGAAS, B;COURCHESNE, E;SAITOH, O
目的：通过磁共振成像确定自闭症患者的后胼胝体中线横截面积是否减少，与之前报道的顶叶异常一致。设计：病例对照研究。设置：三级护理机构。患者和其他参与者：51名自闭症患者（45名男性和6名女性;年龄范围，3至42岁），包括弱智和非弱智患者谁符合几个诊断标准的自闭症。51名年龄和性别匹配的志愿者正常对照组也被包括在内。干预：无。主要结果测量：计算机辅助测量的横截面积，面积的五个分区，和厚度profile.Results：整体尺寸减小，集中在后subregions.Conclusions：证据是发现的胼胝体在自闭症患者的尺寸减小。这种减少局限于后部区域，即顶骨。已知叶状纤维突出。这一发现进一步支持了顶叶受累可能是自闭症的一个一致特征的观点。
Objective: To determine via magnetic resonance imaging if the posterior corpus callosum is reduced in the midline cross-sectional area in autistic patients, consistent with previous reports of parietal lobe abnormalities.Design: Case-control study.Setting: Tertiary care facility.Patients and Other Participants: Fifty-one autistic patients (45 males and six females; age range, 3 to 42 years), including both mentally retarded and nonretarded patients who met several diagnostic criteria for autism were prospectively selected. Fifty-one age- and sex-matched volunteer normal control subjects were also included.Intervention: None.Main Outcome Measures: Computer-aided measurement of cross-sectional area, areas of five subregions, and thickness profile.Results: Overall size reduction, concentrated in posterior subregions.Conclusions: Evidence is found of a reduced size of the corpus callosum in autistic patients. This reduction is localized to posterior regions, where parietal. lobe fibers are known to project. This finding further supports the idea that parietal lobe involvement may be a consistent feature in autism.