Low serum butyrylcholinesterase is independently related to low fetuin-A in patients on hemodialysis: a cross-sectional study
Low serum butyrylcholinesterase is independently related to low fetuin-A in patients on hemodialysis: a cross-sectional study
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DOI：
10.1007/s11255-018-1957-z
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发表时间：
2018-09-01
影响因子：
2
通讯作者：
Ohyama, Chikara
中科院分区：
文献类型：
--
作者：
Okamoto, Teppei;Tsutaya, Chikako;Ohyama, Chikara
目的胎儿球蛋白A在血液透析患者中降低，它对动脉粥样硬化和血管钙化的进展起保护作用。营养不良期间胎球蛋白A和血清丁酰胆碱酯酶（BChE）水平下降。我们探讨是否BChE是独立相关的胎儿球蛋白-A的患者HD。方法实验室数据，包括BChE和血清胎儿球蛋白-A从230例HD 2017年8月至2018年4月。采用老年营养风险指数（GNRI）评估营养状况。腹主动脉钙化指数（ACI）采用计算机断层扫描测量。将患者分为两组：低胎球蛋白-A（<最低四分位数）和非低胎球蛋白-A（>=最低四分位数）组。比较患者背景、药物和实验室数据。采用受试者工作特征分析确定BChE和GNRI在低胎球蛋白A水平时的最佳临界值。结果胎儿球蛋白A的最低四分位值、BChE和GNRI的最佳临界值分别为0.213 g/L、200 IU/L和92.6。该研究分别包括低胎球蛋白A组和非低胎球蛋白A组的57名和173名患者。观察到年龄、C反应蛋白（CRP）、心血管疾病史、血清白蛋白、GNRI和BChE存在显著组间差异。多因素分析表明，
Purpose Fetuin-A, which plays a protective role against the atherosclerosis and progression of vascular calcification, is decreased in patients on hemodialysis (HD). Fetuin-A and serum butyrylcholinesterase (BChE) levels decrease during malnutrition. We explored whether BChE was independently related to fetuin-A in patients on HD.Methods Laboratory data including BChE and serum fetuin-A were acquired from 230 patients on HD between August 2017 and April 2018. Nutritional status was evaluated using the Geriatric Nutritional Risk Index (GNRI). Abdominal aortic calcification index (ACI) was measured using computed tomography. Patients were stratified into two groups: low fetuin-A (< lowest quartile) and non-low fetuin-A (>= lowest quartile) groups. Patient background, medication, and laboratory data were compared. The receiver operating characteristic analysis was conducted to determine the optimal cutoff values of BChE and GNRI for lower fetuin-A level. Factors independently related with lower fetuin-A levels were determined using multivariate logistic regression analysis.Results The lowest quartile value of fetuin-A and optimal cutoff values of BChE and GNRI were 0.213 g/L, 200 IU/L, and 92.6, respectively. The study included 57 and 173 patients in the low fetuin-A and non-low fetuin-A groups, respectively. Significant between-group differences were observed for age, C-reactive protein (CRP), history of cardiovascular disease, serum albumin, GNRI, and BChE. Multivariate analysis showed that BChE of