Potential regenerative rehabilitation technology: implications of mechanical stimuli to tissue health.
Potential regenerative rehabilitation technology: implications of mechanical stimuli to tissue health.
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DOI：
10.1186/1756-0500-7-334
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发表时间：
2014-06-03
影响因子：
1.8
通讯作者：
Shields RK
中科院分区：
文献类型：
--
作者：
McHenry CL;Wu J;Shields RK
通过肌肉收缩、振动或压缩力引起的机械负荷被认为调节组织可塑性。随着再生医学的出现，有必要了解促进细胞健康的最佳机械环境（振动，负荷或肌肉力量）。据我们所知，还没有提出机械系统来在人体组织中传递这些孤立的机械刺激。我们提出的设计，性能和利用的一种新技术，可用于研究局部机械刺激人体组织。开发了一种伺服控制振动和肢体加载系统，并将其集成到单个仪器中，以向人类的单个肢体（胫骨）提供振动、压缩或肌肉收缩载荷。在8名脊髓损伤（SCI）患者身上评价了机械输送系统的准确性、可重复性、可传递性和安全性。肢体加载系统是线性的，可重复的，准确度分别小于满量程的5%，1%和1%，并且传递性非常好。对脊髓损伤（SCI）个体的会话间测试显示出高的类内相关性（>0.9）。所有测试均支持治疗载荷可以安全、准确和可测量的方式输送至下肢（胫骨）。工程师和细胞生理学家之间的未来合作将是重要的，因为研究计划致力于确定人类细胞和组织发育的最佳机械环境。
Mechanical loads induced through muscle contraction, vibration, or compressive forces are thought to modulate tissue plasticity. With the emergence of regenerative medicine, there is a need to understand the optimal mechanical environment (vibration, load, or muscle force) that promotes cellular health. To our knowledge no mechanical system has been proposed to deliver these isolated mechanical stimuli in human tissue. We present the design, performance, and utilization of a new technology that may be used to study localized mechanical stimuli on human tissues. A servo-controlled vibration and limb loading system were developed and integrated into a single instrument to deliver vibration, compression, or muscle contractile loads to a single limb (tibia) in humans. The accuracy, repeatability, transmissibility, and safety of the mechanical delivery system were evaluated on eight individuals with spinal cord injury (SCI). The limb loading system was linear, repeatable, and accurate to less than 5, 1, and 1 percent of full scale, respectively, and transmissibility was excellent. The between session tests on individuals with spinal cord injury (SCI) showed high intra-class correlations (>0.9). All tests supported that therapeutic loads can be delivered to a lower limb (tibia) in a safe, accurate, and measureable manner. Future collaborations between engineers and cellular physiologists will be important as research programs strive to determine the optimal mechanical environment for developing cells and tissues in humans.