Transcutaneous Electrical Nerve Stimulation Improves Stair Climbing Capacity in People with Knee Osteoarthritis
Transcutaneous Electrical Nerve Stimulation Improves Stair Climbing Capacity in People with Knee Osteoarthritis
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DOI：
10.1038/s41598-020-64176-0
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发表时间：
2020-04-29
影响因子：
4.6
通讯作者：
Takahashi, Masaki
中科院分区：
文献类型：
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作者：
Iijima, Hirotaka;Eguchi, Ryo;Takahashi, Masaki
本研究旨在检查经皮神经电刺激（TENS）对患有放射学检查前至轻度膝关节骨关节炎（OA）的个体爬楼梯能力的影响。这是对一项单次、受试者设盲、随机对照试验数据的二次分析，采用前后设计。受试者（平均年龄59.1岁，72.9%为女性）被随机分为两组，TENS组（n=30）和假TENS组（n=29）。通过使用具有预先指定的参数的原型TENS设备对所有参与者进行TENS或假TENS治疗。主要结局指标包括有效和可靠的爬楼梯功能指标（爬楼梯试验[SCT]）、SCT期间膝关节疼痛的视觉模拟量表和股四头肌肌力。TENS使SCT时间延长了0.41 s（95%置信区间[CI]：0.07，0.75）。过渡期的时间减少解释了TENS的治疗效果。事后相关性分析显示，TENS组的疼痛缓解效果与改善的11步SCT时间之间存在非显著但正相关的关系，但假TENS组则无此关系。这些结果表明，TENS干预可能是减轻早期膝关节OA负担的一种选择。
This study aimed to examine the effect of transcutaneous electrical nerve stimulation (TENS) on stair climbing capacity in individuals with pre-radiographic to mild knee osteoarthritis (OA). This is a secondary analysis of data from a single, participant-blinded, randomized controlled trial with a pre-post design. Participants with pre-radiographic to mild knee OA (mean age, 59.1 years; 72.9% women) were randomly assigned into two groups, a TENS (n=30) and a sham-TENS groups (n=29). TENS or sham-TENS treatments were applied to all participants by using the prototype TENS device with pre-specified parameters. The primary outcome measures included valid and reliable functional measures for stair climbing (stair-climb test [SCT]), visual analog scale for knee pain during the SCT, and quadriceps muscle strength. TENS improved SCT time by 0.41s (95% confidence interval [CI]: 0.07, 0.75). The time reduction in the transition phase explains the TENS therapeutic effect. Post-hoc correlation analyses revealed a non-significant but positive relationship between the pain relief effect and improved 11-step SCT time in the TENS group but not in the sham-TENS group. These results indicate that the TENS intervention may be an option for reducing the burden of early-stage knee OA.