Serotonin (5-HT) enhances the activity of amphotericin B against Aspergillus fumigatus in vitro
Serotonin (5-HT) enhances the activity of amphotericin B against Aspergillus fumigatus in vitro
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DOI：
10.1016/j.ijantimicag.2004.03.021
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发表时间：
2004-10-01
影响因子：
10.8
通讯作者：
Lass-Flörl, C
中科院分区：
文献类型：
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作者：
Heller, I;Leitner, S;Lass-Flörl, C
我们研究了5-羟色胺（5-HT）和舍曲林联合阿替霉素B和伊曲康唑对曲霉菌临床分离株的体外协同抗真菌潜力。使用棋盘微量稀释法进行协同试验。测定了对烟曲霉（n = 7）、黄曲霉（n = 3）和土曲霉（n = 2）的活性，并与白色念珠菌和近平滑念珠菌进行了比较。对于测试的各种分离株，部分抑制浓度（FIC）指数范围在0.25和3之间。5-HT能增强阿替霉素B对曲霉菌的抑制作用。5-HT和伊曲康唑以及舍曲林和伊曲康唑或阿曲霉素B的联合研究显示出不同菌株的不同活性，包括协同作用（FIC < 1.0）、相加作用（FIC = 1）和无差异作用（FIC在1.0和2.0之间）。5-HT和舍曲林对C.近平滑(C)2004年，Elsevier B. V.和国际化疗学会。All rights reserved.
We investigated the in vitro synergistic antifungal potential of combining serotonin (5-HT) and sertraline with amphotericin B and itraconazole against clinical isolates of Aspergillus spp. Synergy tests were performed using the chequerboard microdilution method. Activity was measured against Aspergillus fumigatus (n = 7), Aspergillus flavus (n = 3) and Aspergillus terreus (n = 2), and compared with that for Candida albicans and Candida parapsilosis. The fractional inhibitory concentration (FIC) indices ranged between 0.25 and 3 for the various isolates tested. 5-HT was shown to enhance the activity of amphotericin B against Aspergillus spp. Combination studies with 5-HT and itraconazole and with sertraline and itraconazole or amphothericin B showed different activities for the various strains, including synergism (FIC < 1.0), additivity (FIC = 1), and indifference (FIC between 1.0 and 2.0). 5-HT and sertraline showed antagonistic activity (FIC > 2) with amphotericin B and itraconazole against C. parapsilosis. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.