The gene of the protease inhibitor SKALP/elafin is a member of the rest gene family
The gene of the protease inhibitor SKALP/elafin is a member of the rest gene family
复制标题
DOI：
10.1006/bbrc.1996.0594
复制
发表时间：
1996-04-16
影响因子：
3.1
通讯作者：
Ulvsback, M
中科院分区：
文献类型：
--
作者：
Lundwall, A;Ulvsback, M
REST基因家族的成员通常有一个由三个外显子组成的转录单元。第一个和最后一个外显子在成员之间是保守的，而第二个外显子编码几乎所有的成熟蛋白，差异很大。这些已知的REST基因在精囊中高度且几乎完全表达。通过序列分析，我们现在已经确定了蛋白酶抑制剂SKALP/ elafin基因是REST基因家族的新成员。该蛋白在表皮中表达，并像几种REST基因的产物一样，作为转谷氨酰胺酶的底物。我们还在人类第20号染色体的q12区域发现了一个似乎包含转谷氨酰胺酶和REST基因的位点，这提出了酶和底物是否平行进化的问题。(C) 1996学术出版社，Inc.
Members of the REST gene family characteristically have a transcription unit consisting of three exons. The first and the last exon are conserved among members, while the second exon-encoding almost all of the mature protein-differs considerably. These far known REST genes are highly, and almost exclusively, expressed in the seminal vesicles. By sequence analysis we have now identified the gene for the protease inhibitor SKALP/ elafin as a new member of the REST gene family. The protein is expressed in the epidermis and serves, like the product of several REST genes, as substrate for transglutaminase. We have also found what seems to be a locus encompassing both transglutaminases and REST genes centered around the region q12 on the human chromosome 20, raising the question whether the enzymes and substrates have evolved in parallel. (C) 1996 Academic Press, Inc.