Characteristics of saccadic dysmetria in monkeys during reversible lesions of medial cerebellar nuclei.
Characteristics of saccadic dysmetria in monkeys during reversible lesions of medial cerebellar nuclei.
复制标题
小脑内侧核可逆性病变期间猴子扫视性辨距障碍的特征。
DOI：
10.1152/jn.1981.46.4.828
复制
发表时间：
1981
影响因子：
2.5
通讯作者：
J. Hore
中科院分区：
文献类型：
--
作者：
T. Vilis;J. Hore
1.在通过植入间位核和顶核之间（内侧探针）或齿状核外侧（外侧探针）的探针冷却产生的可逆性病变期间，研究了由训练有素的Cebus猴进行的扫视眼球运动的准确性。2.通过外侧探头冷却并不影响垂直或水平扫视的准确性，然而，通过内侧探头冷却产生了测距障碍，其大小取决于眼睛的位置和扫视的方向。3.与正常眼跳相比，测量障碍眼跳的幅度/持续时间关系无显著差异。4.在内侧探头冷却过程中，尽管斜向扫视的水平和垂直分量的轨迹不相等，但这两个分量基本上是直的。这表明，在一个组件中产生测距障碍的机制必须与决定另一个组件持续时间的注视中心相互作用。5.小脑核冷却通过任何一个侧面的内侧探针并没有改变扫视反应时间，以随机定时的步骤变化的目标位置。这一结果与肢体运动的结果不同，在肢体运动中，小脑辨距障碍与反应时间增加有关。6.这些结果提供的证据表明，小脑通过内侧核通常在终止，但不是在启动，扫视中发挥作用。
1. The accuracy of saccadic eye movements made by trained Cebus monkeys was studied during reversible lesions produced by cooling through probes implanted between the interpositus and fastigial nuclei (medial probe) or lateral to the dentate nucleus (lateral probe). 2. Cooling through the lateral probe did not impair the accuracy of vertical or horizontal saccades, However, cooling through the medial probe produced a dysmetria whose magnitude was dependent on the position of the eye and on the direction of the saccade. 3. The amplitude/duration relation of dysmetria saccades was not significantly different from that of normal saccades. 4. The trajectories of the horizontal and vertical components of oblique saccades remained essentially straight during medial probe cooling in spite of unequal dysmetria in the two components. This suggests that the mechanism that produces a dysmetria in one component must interact with the gaze center that determines the duration of the other component. 5. Cerebellar nuclear cooling through either lateral of medial probes did not alter the saccadic reaction time to a randomly timed step change in target position. This result differs from that found for limb movements where cerebellar dysmetria was associated with increased reaction times. 6. These results provide evidence that the cerebellum through the medial nuclei normally plays a role in terminating, but not in initiating, saccades.