Prevalence of Low Testosterone in Men With Cystic Fibrosis and Congenital Bilateral Absence of the Vas Deferens: A Cross-sectional Study Using a Large, Multi-institutional Database.
Prevalence of Low Testosterone in Men With Cystic Fibrosis and Congenital Bilateral Absence of the Vas Deferens: A Cross-sectional Study Using a Large, Multi-institutional Database.
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患有囊性纤维化和先天性双侧输精管缺失的男性睾酮水平低下的患病率：一项使用大型多机构数据库的横断面研究。
DOI：
10.1016/j.urology.2023.08.039
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发表时间：
2023
期刊：
影响因子：
2.1
通讯作者：
Ramasamy,Ranjith
中科院分区：
文献类型：
--
作者：
Campbell,Katherine;Deebel,Nicholas;Kohn,Taylor;Passarelli,Rachel;Velez,Danielle;Ramasamy,Ranjith
目的了解男性囊性纤维化(CF)患者低睾酮(T)的发生率和治疗率。囊性纤维化是一种表现形式多变的遗传性疾病，由囊性纤维化跨膜传导调节因子基因突变引起。CF的表型表现包括肺、肝、胰腺和生殖系统功能的改变。尽管CF与先天性双侧输精管缺如(CBAVD)继发的不孕不育之间的关系已经得到了很好的描述，但患有CF的男性报告了更多的性健康和生殖健康问题，其中许多往往与低睾酮有关。方法我们查询了Trin etX数据库中患有CF或CBAVD的18岁以上男性的T水平，以评估T水平的测量百分比，如果性腺功能低下(低于300 ng/dL)，接受T治疗的百分比(TT)。结果：10.1%的CF患者和8.9%的CBAVD患者的血清T水平被检测到。在每组中，464名CF患者(32.7%)和132名CBAVD患者(43.0%)表现出低T。大多数T<；300 ng/dL的男性继续适当地接受TT：59.3%的CF患者和78%的CBAVD患者。结论我们的数据表明，性腺功能低下症在CF和CBAVD男性中非常普遍。对睾酮缺乏症的调查和适当的治疗可能会显著提高生活质量。
ObjectiveTo investigate the prevalence and treatment rates of low testosterone (T) in men with Cystic Fibrosis (CF). CF is a genetic disease with highly variable presentation that results from a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Phenotypic manifestations of CF include alterations in function of the lungs, liver, pancreas, and reproductive system. Despite the well-described association between CF and infertility secondary to congenital bilateral absence of the vas deferens (CBAVD), men with CF report further sexual and reproductive health concerns, many of which are often associated with low testosterone.MethodsWe queried the TrinetX database for men over 18 years old with CF or CBAVD to assess what percentage of men had a T level measured, and if hypogonadal (below 300 ng/dL), what percentage received T therapy (TT). We hypothesized that low T would be under-evaluated in the CF population.ResultsSerum T levels were measured in 10.1% of men with CF and 8.9% of men with CBAVD. Within each group, 464 men with CF (32.7%) and 132 with CBAVD (43.0%) demonstrated low T. The majority of men with T<300 ng/dL went on to appropriately receive TT: 59.3% of men with CF and 78% with CBAVD.ConclusionOur data suggests that hypogonadism is highly prevalent in men with CF and CBAVD. Investigation and appropriate treatment of testosterone deficiency may significantly improve quality of life.