Controlled Release of Multiple Therapeutics from Silicone Hydrogel Contact Lenses.
Controlled Release of Multiple Therapeutics from Silicone Hydrogel Contact Lenses.
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DOI：
10.1097/opx.0000000000000849
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
Byrne ME
中科院分区：
文献类型：
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作者：
White CJ;DiPasquale SA;Byrne ME
大多数隐形眼镜佩戴者通常在佩戴数小时内经历与镜片佩戴相关的显着程度的眼部不适，这与镜片干燥、炎症、镜片表面的蛋白质粘附等有关。控制药物释放技术的应用集中于从镜片中掺入和/或释放单一舒适分子，包括高分子量舒适剂或药剂。先前的研究试图减轻单一不适传播者的发生。滴眼液的临床研究表明，选择多种舒适剂的混合物来解决多种不适传播因素，可以为患者提供最大、最持久的舒适感。在本文中，通过从新型隐形眼镜中同时释放四种分子来解决多种不适传播因素，以确保高水平的镜片佩戴舒适度。硅水凝胶隐形眼镜通过分子印迹策略进行设计，可同时释放多达四种模板分子，包括羟丙基甲基纤维素（HPMC）、海藻糖、布洛芬和泼尼松龙。通过调整功能单体与舒适分子的比例，对释放速率进行了高水平的控制。 HPMC、海藻糖、布洛芬和泼尼松龙从单个晶状体中以不同的速率以治疗相关浓度释放。结果表明可用作单日释放的日抛镜片或多日释放的长戴型镜片。与局部滴眼剂相比，压印镜片有望通过提高依从性并减轻与多次滴眼相关的浓度峰谷来为患者带来更高的疗效。
The majority of contact lens wearers experience a significant level of ocular discomfort associated with lens wear, often within hours of wear, related to dry lenses, inflammation, protein adhesion to the lens surface, etc. Application of controlled drug release techniques has focused on the incorporation and/or release of a single comfort molecule from a lens including high molecular weight comfort agents or pharmaceutical agents. Previous studies have sought to mitigate the occurrence of only single propagators of discomfort. Clinical studies with eye drop solutions have shown that a mixture of diverse comfort agents selected to address multiple propagators of discomfort provide the greatest and longest lasting sensations of comfort for the patient. In this paper, multiple propagators of discomfort are addressed through the simultaneous release of four molecules from a novel contact lens to ensure high level of lens wear comfort. Silicone hydrogel contact lenses were engineered via molecular imprinting strategies to simultaneously release up to four template molecules including hydropropyl methylcellulose (HPMC), trehalose, ibuprofen, and prednisolone. By adjusting the ratio of functional monomer to comfort molecule, a high level of control was demonstrated over the release rate. HPMC, trehalose, ibuprofen, and prednisolone were released at therapeutically relevant concentrations with varying rates from a single lens. The results indicate use as daily disposable lenses for single day release or extended-wear lenses with multiple day release. Imprinted lenses are expected to lead to higher efficacy for patients compared to topical eye drops by improving compliance and mitigating concentration peaks and valleys associated with multiple drops.