Optical properties of the mouse eye.
Optical properties of the mouse eye.
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DOI：
10.1364/boe.2.000717
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发表时间：
2011-02-28
影响因子：
3.4
通讯作者：
Williams DR
中科院分区：
文献类型：
--
作者：
Geng Y;Schery LA;Sharma R;Dubra A;Ahmad K;Libby RT;Williams DR
Shack-Hartmann波前传感器（SHWS）可以测量眼像差 由于光线从多个视网膜层反射，因此在小鼠中依赖的质量较差。我们有 设计并实现了一种SHWS，可以支持来自特定视网膜层的光， 测量来自10只麻醉的C57 BL/6 J小鼠的20只眼睛的单色像差。使用此 仪器，我们表明小鼠是近视的，而不是经常报道的远视。我们有 还测量了小鼠眼睛的纵向色差（LCA），发现它 根据充满水的示意性老鼠眼睛的预测。结果表明，光学 通过测量其像差评估的小鼠眼睛的质量非常好， 比人眼更适合视网膜成像。扩张的老鼠眼睛有一个更大的数值 孔径（NA）比扩张的人眼（0.5 NA对0.2 NA），但它具有类似的 与扩张的人眼相比，均方根（RMS）高阶像差的量。 这些测量预测，基于这种波前传感方法的自适应光学将 提供视网膜图像质量的改进，并且潜在地提供两倍高的横向 比人眼的分辨率还要高。
The Shack-Hartmann wavefront sensor (SHWS) spots upon which ocular aberration measurements depend have poor quality in mice due to light reflected from multiple retinal layers. We have designed and implemented a SHWS that can favor light from a specific retinal layer and measured monochromatic aberrations in 20 eyes from 10 anesthetized C57BL/6J mice. Using this instrument, we show that mice are myopic, not hyperopic as is frequently reported. We have also measured longitudinal chromatic aberration (LCA) of the mouse eye and found that it follows predictions of the water-filled schematic mouse eye. Results indicate that the optical quality of the mouse eye assessed by measurement of its aberrations is remarkably good, better for retinal imaging than the human eye. The dilated mouse eye has a much larger numerical aperture (NA) than that of the dilated human eye (0.5 NA vs. 0.2 NA), but it has a similar amount of root mean square (RMS) higher order aberrations compared to the dilated human eye. These measurements predict that adaptive optics based on this method of wavefront sensing will provide improvements in retinal image quality and potentially two times higher lateral resolution than that in the human eye.