Prostate fibroblasts enhance androgen receptor splice variant 7 expression in prostate cancer cells
Prostate fibroblasts enhance androgen receptor splice variant 7 expression in prostate cancer cells
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DOI：
10.1002/pros.24468
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发表时间：
2022-12
期刊：
影响因子：
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通讯作者：
Takeshi Sasaki;Yumi Yoshikawa;T. Kageyama;Y. Sugino;Manabu Kato;S. Masui;Kouhei Nishikawa;Takahiro Inoue
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作者：
Takeshi Sasaki;Yumi Yoshikawa;T. Kageyama;Y. Sugino;Manabu Kato;S. Masui;Kouhei Nishikawa;Takahiro Inoue
雄激素受体剪接变异体（AR-V）表达与雄激素剥夺治疗期间前列腺癌（PCa）进展为去势抵抗性PCa相关，这减少了雄激素产生并抑制了PCa细胞中的雄激素作用。然而，PCa中异常AR-V表达增加的机制在很大程度上仍然未知。肿瘤间质中的成纤维细胞影响PCa的启动和侵袭性，并且可能在人类前列腺上皮恶性转化期间引发遗传变化中起关键作用。在这里，我们的目的是确定肿瘤间质中的前列腺成纤维细胞是否在低雄激素浓度下诱导PCa细胞中的异常AR-V7表达。
Androgen receptor splice variant (AR‐V) expression has been associated with prostate cancer (PCa) progression to castration‐resistant PCa during androgen deprivation therapy, which reduces androgen production and inhibits androgen action in PCa cells. However, the mechanisms whereby aberrant AR‐V expression is increased in PCa are still largely unknown. Fibroblasts in tumor stroma influence PCa initiation and aggressiveness, and which may play a crucial role in eliciting genetic changes during malignant transformation in human prostate epithelium. Here, our aim was to determine whether prostate fibroblasts in tumor stroma induce aberrant AR‐V7 expression in PCa cells under low androgen concentration.