Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor.
Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor.
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DOI：
10.3390/v7122970
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发表时间：
2015-12-19
期刊：
影响因子：
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通讯作者：
Fackler OT
中科院分区：
文献类型：
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作者：
Fackler OT
Nef蛋白是由人类免疫缺陷病毒1型和2型（HIV-1/-2）和猿猴免疫缺陷病毒（SIV）编码的辅助基因产物，其促进病毒在感染宿主中的复制并加速疾病进展。与HIV-1辅助蛋白Vif、Vpr和Vpu不同，Nef直到最近才被发现拮抗宿主细胞限制因子的抗病毒活性。最近的两份报告描述了宿主细胞蛋白丝氨酸蛋白酶3和5（SERINC 3和SERINC 5）作为HIV-1颗粒感染性的有效抑制剂，并证明Nef抵消了这些作用。这些发现确立了SERINC 3/5作为HIV在人类细胞中复制的限制，并定义了HIV致病因子Nef的新活性。
The Nef protein is an accessory gene product encoded by human immunodeficiency virus types 1 and 2 (HIV-1/-2) and simian immunodeficiency virus (SIV) that boosts virus replication in the infected host and accelerates disease progression. Unlike the HIV-1 accessory proteins Vif, Vpr and Vpu, Nef was, until recently, not known to antagonize the antiviral activity of a host cell restriction factor. Two recent reports now describe the host cell proteins serine incorporator 3 and 5 (SERINC3 and SERINC5) as potent inhibitors of HIV-1 particle infectivity and demonstrate that Nef counteracts these effects. These findings establish SERINC3/5 as restrictions to HIV replication in human cells and define a novel activity for the HIV pathogenesis factor Nef.