Unravelling cerebellar pathways with high temporal precision targeting motor and extensive sensory and parietal networks
Unravelling cerebellar pathways with high temporal precision targeting motor and extensive sensory and parietal networks
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DOI：
10.1038/ncomms1912
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发表时间：
2012-06-01
影响因子：
16.6
通讯作者：
Thier, Peter
中科院分区：
文献类型：
--
作者：
Sultan, Fahad;Augath, Mark;Thier, Peter
越来越多的证据表明，小脑提供了预测动作的感觉后果的运动植物的正向模型。假设小脑对大脑皮层的输入通过添加前向模型信号而有助于大脑皮层的处理，我们将期望找到强调运动和感觉皮层区域的投射。然而，这一期望只有部分满足小脑-大脑连接的研究。在这里，我们表明，通过电刺激小脑的输出和功能磁共振成像成像的成像反应，诱发的血氧水平依赖性活动观察不仅在经典的小脑投射目标，初级运动皮层，但也在一些额外的领域在岛叶，顶叶和枕叶皮层，包括感觉皮层的代表。对这些反应的进一步探索揭示了一个经过优化的投射系统，可以快速传递和暂时精确的信息。总之，无论是地形的刺激效果和它的时间精度的重点是完全符合小脑前向模型的信息调制皮层处理的概念。
Increasing evidence has implicated the cerebellum in providing forward models of motor plants predicting the sensory consequences of actions. Assuming that cerebellar input to the cerebral cortex contributes to the cerebro-cortical processing by adding forward model signals, we would expect to find projections emphasising motor and sensory cortical areas. However, this expectation is only partially met by studies of cerebello-cerebral connections. Here we show that by electrically stimulating the cerebellar output and imaging responses with functional magnetic resonance imaging, evoked blood oxygen level-dependant activity is observed not only in the classical cerebellar projection target, the primary motor cortex, but also in a number of additional areas in insular, parietal and occipital cortex, including sensory cortical representations. Further probing of the responses reveals a projection system that has been optimized to mediate fast and temporarily precise information. In conclusion, both the topography of the stimulation effects and its emphasis on temporal precision are in full accordance with the concept of cerebellar forward model information modulating cerebro-cortical processing.