Transcription of the kinetoplastid spliced leader RNA gene
Transcription of the kinetoplastid spliced leader RNA gene
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DOI：
10.1016/s0169-4758(99)01545-8
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发表时间：
2000-02-01
期刊：
影响因子：
--
通讯作者：
Yu, MC
中科院分区：
文献类型：
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作者：
Campbell, DA;Sturm, NR;Yu, MC
近年来，人们对动质体剪接体（SL）RNA基因转录调控的顺式元件有了更多的了解。SL RNA基因含有前39个核苷酸，这些核苷酸反式剪接到这些生物体中所有核衍生的mRNA上。转录起始由两个精确间隔的上游元件决定，转录终止由下游多聚T束指导，尽管负责SL RNA合成的RNA聚合酶仍然受到质疑。br这篇文章，大卫坎贝尔，南希Sturm和Michael Yu回顾了动质体SL RNA基因转录的领域，根据目前的数据解决过去的建议，并讨论了文献中出现的一些差异。
In recent years, much has been learned about the cis-elements controlling transcription of the kinetoplastid spliced lender (SL) RNA gene. The SL RNA gene contains the first 39 nucleotides that are trans-spliced on to all nuclear-derived mRNAs in these organisms. Transcription initiation is determined by two precisely spaced upstream elements and transcription termination is directed by the downstream poly-T tract, although the RNA polymerase responsible for SL RNA synthesis is still questioned. br this article, David Campbell, Nancy Sturm and Michael Yu review the field of kinetoplastid SL RNA gene transcription, address past proposals in light of current data and discuss some of the differences that appear in the literature.