Optimized acquisition and processing protocols for 1-123 cardiac SPECT imaging
Optimized acquisition and processing protocols for 1-123 cardiac SPECT imaging
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DOI：
10.1016/j.nuclcard.2006.01.017
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发表时间：
2006-03-01
影响因子：
2.4
通讯作者：
Carrio, I
中科院分区：
文献类型：
--
作者：
Chen, J;Garcia, EV;Carrio, I
背景。隔膜穿透解卷积 (DSP) 已被开发用于改进量化，以便允许使用低能量高分辨率准直器进行碘 123 心脏单光子发射计算机断层扫描 (SPECT) 成像。本研究的目的是优化其采集和处理协议。方法和结果。获取装载有可变放射性浓度的 9 室体模的平面图像，以分别得出 20% 和 15% 光峰能量窗口配置的最佳散射补偿缩放因子。分别加载高和低心脏校准比 (HCR) 的心脏体模，使用两种配置进行成像。对中能通用准直器进行了重复采集以进行比较。通过使用缺陷对比度和正常短轴均匀性作为选择指标来优化巴特沃斯滤波的临界频率。 HCR；分别用平面投影和不同的重建方法计算，然后与真实的HCR进行比较。 SPECT 产生的 HCR 比平面成像更准确。通过优化散射补偿和滤波参数，两种能量窗口配置产生了相似的结果。使用 DSP 的迭代重建比不使用 DSP 的其他重建产生更准确的 HCR。结论。基于 DSP 的优化协议表明，可以使用广泛使用的低能量高分辨率准直器来实现 I-123 心脏 SPECT 成像的量化。
Background. Deconvolution of septal penetration (DSP) has been developed to improve quantification so as to allow the use of low-energy high-resolution collimators for iodine 123 cardiac single photon emission computed tomography (SPECT) imaging. The purpose of this study is to optimize its acquisition and processing protocols.Methods and Results. Planar images of a 9-compartment phantom loaded with variable radioactive concentrations were acquired to derive optimal scatter compensation scaling factors for 20% and 15% photopeak energy window configurations, respectively. A cardiac phantom, loaded with high and low heart-to-calibration ratios (HCRs), respectively, was imaged with both configurations. Repeated acquisitions were done for medium-energy all-purpose collimators for comparison. Critical frequencies for Butterworth filtering were optimized by use of defect contrast and normal short-axis uniformity as selection indices. HCRs; were calculated with planar projection and different reconstruction methods, respectively, and then compared with the true HCRs. SPECT produced more accurate HCRs than planar imaging. With the optimized parameters for scatter compensation and filtering, the 2 energy window configurations yielded similar results. Iterative reconstructions with DSP yielded more accurate HCRs than other reconstructions without DSP.Conclusion. The optimized protocols based on DSP show promise that quantification of I-123 cardiac SPECT imaging can be achieved with the widely available low-energy highresolution collimators.