Hybrid Mock Circulatory Loop Simulation of Extreme Cardiac Events.
Hybrid Mock Circulatory Loop Simulation of Extreme Cardiac Events.
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DOI：
10.1109/tbme.2022.3156963
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发表时间：
2022-09
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本文提出了将心律失常和瓣膜狭窄的病理条件纳入混合模拟循环回路（hMCL）操作中的初步方法，以增强机械循环支持装置（例如 VAD）的验证和验证。来自 PhysioNet 数据库的 MGH/MF 波形数据集（包括名义和临床诊断的心律失常心电图测量）以及心血管系统模型更新用于在体外重建心律失常事件和瓣膜狭窄。初步结果显示，hMCL 可以分别在主动脉和左心室压力室中参考压力跟踪的平均误差在 2% 和 4% 之内重建每个测试的心脏事件。此外，使用幅值平方相干性分析进行的频谱分析比较显示，测量的心律失常和 hMCL 实现的压力频率内容之间紧密一致。通过基于模型和急性测量的方法，实现了 VAD 周围心律失常和瓣膜狭窄的产生。尽管有很大比例的患者经历过这些事件，但心律失常和瓣膜狭窄等病理状况的记录有限。本文提供了一种方法来开始将这些事件合并到硬件在环模拟循环系统中，以进行下一代 VAD 验证和验证。
This paper presents preliminary methods of incorporating the pathological conditions of cardiac arrhythmias and valvular stenosis in hybrid mock circulation loop (hMCL) operation for the enhanced verification and validation of mechanical circulatory support devices such as VADs. The MGH/MF Waveform datasets from PhysioNet database (including both nominal and clinically diagnosed arrhythmic ECG measurements) as well as cardiovascular system model updates are used to recreate arrhythmic events and valvular stenosis in vitro. Preliminary results show the hMCL can recreate each tested cardiac event within 2% and 4% mean error for reference pressure tracking in the aortic and left ventricular pressure chambers, respectively. Further, frequency spectrum analysis comparisons using the magnitude-squared coherence analysis shows close alignment between measured arrhythmic and hMCL realized pressure frequency content. The generation of cardiac arrhythmias and valvular stenosis around a VAD via both model and acute measurement based methods was achieved. Pathological conditions such as cardiac arrhythmias and valvular stenosis are limited in documentation despite the large percentage of patients who experience these events. This paper provides a means to begin incorporating these events into hardware-in-the-loop mock circulatory systems for next generation VAD validation and verification.