Deletion of C-reactive protein ameliorates experimental cerebral malaria?
Deletion of C-reactive protein ameliorates experimental cerebral malaria?
复制标题
删除 C 反应蛋白可改善实验性脑型疟疾？
DOI：
10.1093/trstmh/tru098
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发表时间：
2014
影响因子：
2.2
通讯作者：
Ramos,TheresaN
中科院分区：
文献类型：
--
作者：
Szalai,AlexanderJ;Barnum,ScottR;Ramos,TheresaN
背景C反应蛋白（CRP）水平与疟疾的寄生虫血症和严重程度相关，但这是否反映了因果关系仍不清楚。方法用伯氏疟原虫ANKA（PbA）诱导的实验性脑型疟疾（ECM），比较CRP转基因小鼠和CRP缺陷小鼠的发病和严重程度。结果CRP缺陷小鼠对ECM的抵抗力最强。结论CRP可能参与脑型疟疾的发生发展，而不是保护脑型疟疾。
Background C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown. Methods Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA). Results CRP-deficient mice were most resistant to ECM. Conclusions CRP might contribute to the development of cerebral malaria, rather than protect against it.