RNA IS SYNTHESIZED AT THE NUCLEAR CAGE
RNA IS SYNTHESIZED AT THE NUCLEAR CAGE
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DOI：
10.1038/292552a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
COOK, PR
中科院分区：
文献类型：
--
作者：
JACKSON, DA;MCCREADY, SJ;COOK, PR
米勒和他的同事拍摄的“作用中的基因”的显微照片惊人地展示了真核基因的转录是由RNA聚合酶沿着DNA1，2移动的。尽管完成的转录本可能与亚核结构3-7有关，但移动聚合酶沿着DNA进行的观点仍然没有受到质疑。在这里，我们考察了另一种观点--当DNA通过固定在亚核结构上的转录复合体时，转录发生，我们证明了转录的序列与我们称为核笼的亚核结构密切相关。
The photomicrographs of ‘genes in action’ taken by Miller and colleagues strikingly illustrate transcription of eukaryotic genes by RNA polymerase moving along the DNA1,2. Although completed transcripts may be associated with sub-nuclear structures3–7, the view that a mobile polymerase processes along the DNA remains unchallenged. Here we examine an alternative view—that transcription occurs as DNA passes through a transcription complex fixed to a sub-nuclear structure, and we show that transcribed sequences are closely associated with a sub-nuclear structure that we call a nuclear cage.