Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam
Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam
复制标题
DOI：
10.1086/317940
复制
发表时间：
2001-01-15
影响因子：
6.4
通讯作者：
Dougan, G
中科院分区：
文献类型：
--
作者：
Dunstan, SJ;Stephens, HA;Dougan, G
研究了主要组织相容性复合体（MHC）Ⅱ类和Ⅲ类基因座对伤寒易感性的影响。对来自越南南部2个不同地理位置的血培养确诊伤寒患者和对照组进行HLA-DRB 1和HLA-DQB 1等位基因、编码肿瘤坏死因子（TNF）-β（TNFA [-238]和TNFA [-308]）的基因、编码α-光毒素的基因和TNF-α微卫星等位基因的基因分型。HLA-DRB 1 *0301/6/8、HLA-DQB 1 *0201-3和TNFA*2（-308）与伤寒易感性相关，而HLA-DRB 1 *04、HLA-DQB 1 *0401/2和TNFA*1（-308）与疾病抵抗相关。估计了3个单独相关基因座的所有可能单倍型的频率，发现伤寒病例患者和对照受试者中存在显著差异（chi（2）= 55.56，32 df; P = .006）。保护性单倍型（TNFA*1 [-308. DRB 1 *04]）或易患伤寒的单倍型（TNFA*2 [-308. DRB 1 *04]）。DRB1*0301）。这份报告确定了人类伤寒和MHC II类和III类基因之间的遗传关联。
The influence of genes of the major histocompatibility complex (MHC) class II and class III loci on typhoid fever susceptibility was investigated. Individuals with blood culture-confirmed typhoid fever and control subjects from 2 distinct geographic locations in southern Vietnam were genotyped for HLA-DRB1 and HLA-DQB1 alleles, the gene that encodes tumor necrosis factor (TNF)-beta (TNFA [-238] and TNFA [-308]), the gene that encodes lymphotoxin-alpha, and alleles of the TNF-alpha microsatellite. HLA-DRB1*0301/6/8, HLA-DQB1*0201-3, and TNFA*2 (-308) were associated with susceptibility to typhoid fever, whereas HLA-DRB1*04, HLA-DQB1*0401/2, and TNFA*1 (-308) were associated with disease resistance. The frequency of all possible haplotypes of the 3 individually associated loci were estimated and were found to be significantly different in typhoid case patients and control subjects (chi (2) = 55.56, 32 df; P = .006). Haplotypes that were either protective (TNFA*1 [-308].DRB1*04) or predisposed individuals to typhoid fever (TNFA*2 [-308]. DRB1*0301) were determined. This report identifies a genetic association in humans between typhoid fever and MHC class II and III genes.