Nerve density in cancer: Less is better.
Nerve density in cancer: Less is better.
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DOI：
10.1096/fba.2021-00046
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发表时间：
2021-10
影响因子：
2.7
通讯作者：
D'Silva NJ
中科院分区：
文献类型：
--
作者：
Schmitd LB;Perez-Pacheco C;D'Silva NJ
癌症中的神经密度正在成为与患者生存相关的临床参数。肿瘤微环境中的神经与较差的生存率和复发有关，特别是当涉及神经周围侵犯时。然而，通常肿瘤内只有少数神经受到神经周围侵袭的影响，而大多数神经则不然。机制研究表明，神经分泌因子促进肿瘤生长和侵袭，从而使肿瘤更具侵袭性。因此，肿瘤微环境中的神经总数应该比神经周围侵犯更能代表神经-肿瘤生物相互作用。这篇综述总结了关于神经密度作为癌症临床结果衡量标准的可用临床信息，并探讨了癌症中神经密度的潜在机制，特别是神经发生、轴突发生和向神经性。
The density of nerves in cancer is emerging as a relevant clinical parameter for patient survival. Nerves in the tumor microenvironment have been associated with poor survival and recurrence, particularly if involved in perineural invasion. However, usually only a few nerves inside a tumor are affected by perineural invasion, while most nerves are not. Mechanistic studies have shown nerve‐secreted factors promote tumor growth and invasion thereby making tumors more aggressive. Therefore, the overall number of nerves in the tumor microenvironment should be more representative of the nerve‐tumor biological interaction than perineural invasion. This review summarizes the available clinical information about nerve density as a measure of clinical outcome in cancer and explores the mechanisms underlying nerve density in cancer, specifically, neurogenesis, axonogenesis, and neurotropism.