Localization and characterization of speech arrest during transcranial magnetic stimulation
Localization and characterization of speech arrest during transcranial magnetic stimulation
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DOI：
10.1016/s1388-2457(99)00047-4
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发表时间：
1999-06-01
影响因子：
4.7
通讯作者：
Davey, KR
中科院分区：
文献类型：
--
作者：
Epstein, CM;Meador, KJ;Davey, KR
目的：探讨重复经颅磁刺激（rTMS）引起的言语阻滞的解剖和生理定位，并探讨言语阻滞与语言功能的关系。方法：10名正常的右撇子志愿者在rTMS期间接受了一系列语言任务测试。其中四人在左额叶区域的1厘米网格上进行了语言停止映射。右脸和手的复合运动动作电位被映射到同一个网格上。在三维MRI上确定了两名受试者言语停止和肌肉激活的平均位置。结果：所有受试者在rTMS期间均出现左侧额后下区自发言语和大声朗读的偏侧停止。写作、理解、重复、命名、口语练习和唱歌相对较少
Objective: To determine the anatomic and physiologic localization of speech arrest induced by repetitive transcranial magnetic stimulation (rTMS), and to examine the relationship of speech arrest to language function.Methods: Ten normal, right-handed volunteers were tested in a battery of language tasks during rTMS. Four underwent mapping of speech arrest on a 1 cm grid over the left frontal region. Compound motor action potentials from the right face and hand were mapped onto the same grid. Mean positions for speech arrest and muscle activation were identified in two subjects on 3-dimensional MRI.Results: All subjects had lateralized arrest of spontaneous speech and reading aloud during rTMS over the left posterior-inferior frontal region. Writing, comprehension, repetition, naming, oral praxis, and singing were relatively spared(P