HIV incidence among men who have sex with men in China: a meta-analysis of published studies.
HIV incidence among men who have sex with men in China: a meta-analysis of published studies.
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DOI：
10.1371/journal.pone.0023431
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Chen XS
中科院分区：
文献类型：
--
作者：
Li HM;Peng RR;Li J;Yin YP;Wang B;Cohen MS;Chen XS
男男性行为者（MSM）已成为我国艾滋病防治的重点人群之一。掌握男男性行为人群中艾滋病的发病情况，对于描述艾滋病在该人群中的传播情况和预测其发展趋势具有重要意义。我们回顾了有关中国男男性接触者HIV感染率的文献。检索Medline数据库和两个中文电子出版物数据库2005年1月至2010年9月的相关研究。使用综合荟萃分析软件进行随机效应发生率的点估计以及相应的HIV感染的95%置信区间（CI）。分别检查亚组分析，按研究设计和地理位置分层。确定了12项研究，包括3项队列研究和9项横断面研究。亚组分析显示，队列和横断面研究的亚总体发生率估计值分别为3.5%（95% CI，1.7%-5.3%）和6.7%（95% CI，4.8%-8.6%）（亚总体之间的差异，Q = 5.54，p = 0.02）;重庆和其他地区的研究分别为8.3%（95%CI，6.9%~ 9.7%）和4.6%（95%CI，2.4%~ 6.9%）（亚工作服间差异，Q = 7.58，p<0.01）。梅毒感染（RR = 3.33，p<0.001）、多个性伴侣（RR = 2.81，p<0.001）和过去6个月内无保护的接受性肛交（RR = 3.88，p = 0.007）是HIV血清转换的显著风险。 这项荟萃分析的结果表明，艾滋病毒的发病率是在中国的男男性接触者的实质。艾滋病毒感染的高发病率和这一人群中危险性行为的独特模式是采取行动的呼吁，应采取创新的社会和公共卫生干预战略，并制定生物预防战略。
Men who have sex with men (MSM) have now become one of the priority populations for prevention and control of HIV pandemic in China. Information of HIV incidence among MSM is important to describe the spreading of the infection and predict its trends in this population. We reviewed the published literature on the incidence of HIV infection among MSM in China. We identified relevant studies by use of a comprehensive strategy including searches of Medline and two Chinese electronic publication databases from January 2005 to September 2010. Point estimate of random effects incidence with corresponding 95% confidence intervals (CI) of HIV infection was carried out using the Comprehensive Meta-Analysis software. Subgroup analyses were examined separately, stratified by study design and geographic location. Twelve studies were identified, including three cohort studies and nine cross-sectional studies. The subgroup analyses revealed that the sub-overall incidence estimates were 3.5% (95% CI, 1.7%–5.3%) and 6.7% (95% CI, 4.8%–8.6%) for cohort and cross-sectional studies, respectively (difference between the sub-overalls, Q = 5.54, p = 0.02); and 8.3% (95% CI, 6.9%–9.7%) and 4.6% (95% CI, 2.4%–6.9%) for studies in Chongqing and other areas, respectively (difference between the sub-overalls, Q = 7.58, p<0.01). Syphilis infection (RR = 3.33, p<0.001), multiple sex partnerships (RR = 2.81, p<0.001), and unprotected receptive anal intercourse in the past six months (RR = 3.88, p = 0.007) represented significant risk for HIV seroconversion. Findings from this meta-analysis indicate that HIV incidence is substantial in MSM in China. High incidence of HIV infection and unique patterns of sexual risk behaviors in this population serve as a call for action that should be answered with the innovative social and public health intervention strategies, and development of biological prevention strategies.
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DOI：
10.1097/qai.0b013e3181c7df71
发表时间：
2010-02
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Feng Y;Wu Z;Detels R
通讯作者：
Detels R
影响因子：
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作者：
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DOI：
10.1126/science.1193748
发表时间：
2010-09-03
期刊：
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影响因子：
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CAPRISA 004 Trial Group
影响因子：
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