3 ADDITIONAL INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS - MOLECULAR-CLONING AND DIFFERENTIAL LOCALIZATION IN BRAIN AND PERIPHERAL-TISSUES
3 ADDITIONAL INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS - MOLECULAR-CLONING AND DIFFERENTIAL LOCALIZATION IN BRAIN AND PERIPHERAL-TISSUES
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DOI：
10.1073/pnas.89.10.4265
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发表时间：
1992-05-15
影响因子：
11.1
通讯作者：
ULLRICH, A
中科院分区：
文献类型：
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作者：
ROSS, CA;DANOFF, SK;ULLRICH, A
从小鼠胎盘cDNA文库中克隆了三个1，4，5-三磷酸肌醇受体（IP 3R）cDNA，命名为IP 3R-II、-III和-IV。这三个跨膜结构域M7和M8与最初克隆的小脑IP 3R-I具有很强的同源性，分歧主要是胞质结构域。三种另外的IP 3R的mRNA水平通常显著低于IP 3R-I，尽管在胃肠道中IP 3R-III的水平可以与IP 3R-I相当。小脑浦肯野细胞表达至少两个，可能是三个不同的IP 3受体，这表明IP 3行动在一个单一的细胞内的异质性。
Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned from a mouse placenta cDNA library. All three display strong homology in membrane-spanning domains M7 and M8 to the originally cloned cerebellar IP3R-I, with divergences predominantly cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting heterogeneity of IP3 action within a single cell.