ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation
ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation
复制标题
ACC 到背内侧纹状体的输入调节组胺能瘙痒感觉。
DOI：
10.1523/jneurosci.3466-17.2018
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发表时间：
2018-04-11
影响因子：
5.3
通讯作者：
Liu, Jing-Gen
中科院分区：
文献类型：
--
作者：
Lu, Yu-Chen;Wang, Yu-Jun;Liu, Jing-Gen
痒是一种不愉快的感觉，会引发抓痒行为。痒抓反应是一种复杂的现象，涉及到调节感觉、情绪、认知和动机方面的棘上结构。然而，瘙痒过程的中枢机制以及棘上区和脊髓在调节瘙痒-抓伤过程中的相互作用尚不清楚。本研究表明，从前扣带皮层（ACC）到背内侧纹状体（DMS）的神经投射构成了雄性C57BL/6J小鼠大脑中调节瘙痒相关行为的关键电路元件。此外，我们证明ACC-DMS投射选择性地调节组胺能，而不是非组胺能，瘙痒相关行为。此外，ACC-DMS投影的光激活对热、机械和化学刺激引起的疼痛行为也没有显著影响，除了缓解福尔马林和完全弗氏佐剂引起的炎症性疼痛。我们进一步证明，脊髓背侧通过B5-I神经元对ACC-DMS投射的瘙痒信号施加抑制作用，B5-I神经元代表了一群介导瘙痒抑制的脊髓抑制性中间神经元。因此，本研究首次提供了ACC-DMS投射调节组胺能性瘙痒相关行为的证据，并揭示了组胺能性瘙痒调节中棘上和脊髓水平之间的相互作用。
Itch is an unpleasant sensation that initiates scratching behavior. The itch-scratch reaction is a complex phenomenon that implicates supraspinal structures required for regulation of sensory, emotional, cognitive, and motivational aspects. However, the central mechanisms underlying the processing of itch and the interplay of the supraspinal regions and spinal cord in regulating itch-scratch processes are poorly understood. Here, we have shown that the neural projections from anterior cingulate cortex (ACC) to dorsal medial striatum (DMS) constitute a critical circuit element for regulating itch-related behaviors in the brains of male C57BL/6J mice. Moreover, we demonstrate that ACC-DMS projections selectively modulate histaminergic, but not nonhistaminergic, itch-related behavior. Furthermore, photoactivation of ACC-DMS projections has also no significant effects on pain behavior induced by thermal, mechanical, and chemical stimuli except for a relief on inflammatory pain evoked by formalin and complete Freund's adjuvant. We further demonstrate that the dorsal spinal cord exerts an inhibitory effect on itch signal from ACC-DMS projections through B5-I neurons, which represent a population of spinal inhibitory interneurons that mediate the inhibition of itch. Therefore, this study presents the first evidence that the ACC-DMS projections modulate histaminergic itch-related behavior and reveals an interplay between the supraspinal and spinal levels in histaminergic itch regulation.