EBV persistence in memory B cells in vivo
EBV persistence in memory B cells in vivo
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DOI：
10.1016/s1074-7613(00)80622-6
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发表时间：
1998-09-01
期刊：
影响因子：
32.4
通讯作者：
Thorley-Lawson, DA
中科院分区：
文献类型：
--
作者：
Babcock, GJ;Decker, LL;Thorley-Lawson, DA
Epstein-Barr 病毒在体外通过激活人类 B 细胞成为增殖性母细胞来建立潜伏期，但在体内它是良性的。在外周血中，病毒潜伏在静息 B 细胞中，我们现在证明这些 B 细胞仅限于 slgD(-) 记忆子集。然而，在扁桃体中，病毒没有表现出这种限制。我们认为 EBV 不加区别地感染粘膜淋巴组织中的 B 细胞，并且这些细胞分化为静息记忆 B 细胞，然后进入循环系统。激活到潜伏期的胚芽阶段是该过程中重要的中间步骤。因此，EBV 可能通过利用产生和维持长期 B 细胞记忆的机制而持续存在。
Epstein-Barr virus establishes latency in vitro by activating human B cells to become proliferating blasts, but in vivo it is benign. In the peripheral blood, the virus resides latently in resting B cells that we now show are restricted to the slgD(-) memory subset. However, in tonsils the virus shows no such restriction. We propose that EBV indiscriminately infects B cells in mucosal lymphoid tissue and that these cells differentiate to become resting memory B cells that then enter the circulation. Activation to the blastoid stage of latency is an essential intermediate step in this process. Thus, EBV may persist by exploiting the mechanisms that produce and maintain long-term B cell memory.